| 肝硬化患者血浆及胃粘膜内血管活性肠肽和生长抑素含量的变化及意义 |
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| 引用本文： | 谢勇,王崇文,祝金泉,张昆和,周美珍.肝硬化患者血浆及胃粘膜内血管活性肠肽和生长抑素含量的变化及意义[J].中华肝脏病杂志,1995(3). |
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| 作者姓名： | 谢勇 王崇文 祝金泉 张昆和 周美珍 |
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| 作者单位： | 江西医学院附一院消化科 |
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| 摘 要： | 采用放射免疫测定法研究了肝硬化（ＨＣ）患者血浆及胃粘膜内血管活性肠肽（ＶＩＰ）和生长抑素（ＳＳ）含量变化及其意义。结果表明：肝硬化患者血浆和胃粘膜内的ＶＩＰ含量和ＳＳ含量均显著高于正常对照组（Ｐ＜０．０１）；ＨＣ伴溃疡病患者血浆及胃粘膜中ＳＳ含量显著高于无溃疡的ＨＣ患者（Ｐ＜０．０５）；血浆及胃粘膜中ＶＩＰ的含量随着胃、十二指肠粘膜充血程度的加剧而升高；并且血浆及胃粘膜内ＶＩＰ和ＳＳ含量与肝功能密切相关。提示：在ＨＣ时存在着严重的胃肠激素代谢率乱，并且它在ＨＣ的病理生理机制和ＨＣ时胃肠功能改变和病理变化中起着重要作用。
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| 关 键 词： | 肝硬化，血管活性肠肽，生长抑素 |
CHANGE OF VASOACTIVE INTESTINAL PEPTIDE AND SOMATOSTATIN CONTENTS IN
PLASMA AND GASTEIC MUCOSA AND THEIR SIGNIFICANCE IN PATIENTS WITH
HEPATIC CIRRHOSIS |
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| Xie Yong,Cong-wen,Zhu jing-quan,et al..CHANGE OF VASOACTIVE INTESTINAL PEPTIDE AND SOMATOSTATIN CONTENTS IN
PLASMA AND GASTEIC MUCOSA AND THEIR SIGNIFICANCE IN PATIENTS WITH
HEPATIC CIRRHOSIS[J].Chinese Journal of Hepatology,1995(3). |
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| Authors: | Xie Yong Cong-wen Zhu jing-quan |
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| Institution: | Xie Yong,Cong-wen,Zhu jing-quan,et al.The First
Affiliated Hospital,Jianxi Medical College,330006 |
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| Abstract: | The
contents of vasoactive intestinal peptide(VIP) and somatostatin(SS)
in palsma and gastric mucosa in patients with hepatic cirrhosis(HC)
were tested by redioimmunoassay. The results showed that the contents
of VIP and SS in patients with HC were significantly higher than in
normal subjects(P<0.01);the contents of SS in cases of HC with peptic
ulcer were sinificantly higher than that without peptic
ulcer(P<0.05).A positive correlation was noted between contents of
VIP and the degree of con- gestion of gastroduodeual
mucosa(P<0.05) and esophageal varices(P<0.05).There was a negative
corre-lation between contents of VIP,SS and albnmin(P<0.01)and a
positive correlation between contents of VIP,SS and prothrombin
time(P<0.01),The results suggest that there was severe disorder of
gastrointestinal hormones in patients with HC. |
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| Keywords: | Hepatic cirrhosis Vasoactive intestial paptide Somatostatin |
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