与眼底病治疗相关的若干临床基础研究现状与挑战

眼底病(如年龄相关性黄斑变性和遗传性视网膜病)导致的失明和低视力是眼科医师目前遇到的棘手问题之一。提高眼底病诊断与治疗水平有赖于眼底病临床基础研究的突破。目前在干细胞移植研究、胚胎干细胞和视网膜干／祖细胞定向发育、微环境研究以及视网膜色素上皮细胞和虹膜色素上皮细胞的移植等方面已经取得了一些阶段性成果,但要较好地解决目前仍然存在的问题,尚需要在发育基因的测定、表达调控与修饰、干／祖细胞的定向分化以及宿主移植区域微环境的完善等等方面给予深入的研究。(中华眼科杂志,2005,41：97-99)

Actuality and challenge of the clinical basic researches related to ocular fundus diseases

The visual loss caused by fundus diseases such as age related macular degeneration and inherited retinal diseases is one of the toughest subjects in preventing blindness. The level of basic researches determines the progress of diagnosis and treatment for them. Although some fruits have been got these years in the fields of stem cell identification, transplantation and differentiation, local environment of survival cells and replacement of retinal pigment epithelium by iris pigment epithelium, many questions still remain to be elucidated about the regulation of gene expression and developmental environment. These answers will benefit the development of novel therapeutic approaches for refractory fundus dysfunctions finally.(Chin J Ophthalmol,2005,41:97-99)