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Increased potency of an inactivated trivalent polio vaccine with oil-in-water emulsions |
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| Authors: | Baldwin Susan L Fox Christopher B Pallansch Mark A Coler Rhea N Reed Steven G Friede Martin |
| Institution: | a Infectious Disease Research Institute, 1124 Columbia St, Suite 400, Seattle, WA 98104, USA b Polio and Picornavirus Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G17, Atlanta, GA 30333, USA c Immune Design Corp, 1124 Columbia Street, Suite 700, Seattle, WA 98104, USA d Initiative for Vaccine Research, World Health Organization, 20 Avenue Appia, CH-12211, Geneva 27, Switzerland |
| Abstract: | The use of inactivated poliovirus vaccines (IPV) will be required to achieve, world-wide eradication of polio. The current expense of IPV is however prohibitive for, some countries, and therefore efforts to decrease the costs of the vaccine are a high, priority. Our results show that the addition of oil-in-water emulsion adjuvants to an, inactivated trivalent poliovirus vaccine are dose-sparing and are capable of enhancing, neutralizing antibody titers in the rat potency model. |
| Keywords: | IPV Adjuvant Oil-in-water |
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