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Pneumococcal serotype distribution and antimicrobial resistance in Chinese children hospitalized for pneumonia |
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| Authors: | Yao Kai-Hu Wang Li-Bo Zhao Gen-Ming Zheng Yue-Jie Deng Li Huang Jing-Fu Wang Jie-Xiu Zhao Rui-Zhen Deng Qiu-Lian Hu Ying-Hui Yu Sang-Jie Yang Yong-Hong Young Mariano |
| Institution: | a Beijing Pediatric Research Institute, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, China b Pediatric Hospital of Fudan University, Shanghai, China c School of Public Health, Fudan University, Shanghai, China d Shenzhen Children's Hospital, Shenzhen, China e Guangzhou Children's Hospital, Guangzhou, China f Tianjin Children's Hospital, Tianjin, China g Tianjin Disease Prevention and Control Center, Tianjin, China h Pulmonology Department of Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, China i Wyeth Pharmaceuticals Inc. China, Shanghai, China |
| Abstract: | A prospective study was performed to determine serotype distribution and antimicrobial resistance in Streptococcus pneumoniae (S. pneumoniae) from Chinese children <5 years old meeting pneumonia criteria. A total of 3865 children were enrolled and 338 S. pneumoniae isolates were obtained. The most frequent serotypes were 19F (55.6%), 19A (13.9%), 23F (10.1%), 6B (4.7%), and 14 (3.6%). The 7-, 10- and 13-valent conjugate vaccines, respectively, covered 76.3%, 76.9%, and 92.3% of isolates. Out of the isolates, six (1.8%) were penicillin resistant. All except 1 of the isolates were resistant to erythromycin. Serotype 19A showed the highest drug resistance. The use of PCV7 has the potential to prevent a substantial number of pneumococcal infections. However, PCV13 is likely to prevent more episodes of pneumococcal disease in China because of the high rates of 19A. |
| Keywords: | Streptococcus pneumoniae Serotype Drug resistance |
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