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Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression
Authors:Kadri Andre  Olli Kampman  Eija Setälä-Soikkeli  Merja Viikki  Outi Poutanen  Timo Nuolivirta  Nina Mononen  Terho Lehtimäki  Esa Leinonen  Ari Illi
Institution:1. Medical School, University of Tampere, 33014, Tampere, Finland
2. P?ij?t-H?me Social and Health Care District, Lahti, Finland
5. Department of Psychiatry, Sein?joki Hospital District, Sein?joki, Finland
4. Department of Psychiatry, Kanta-H?me Central Hospital, H?meenlinna, Finland
3. Department of Psychiatry, Tampere University Hospital, Tampere, Finland
6. Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
7. Department of Clinical Chemistry, Medical School, University of Tampere, Tampere, Finland
Abstract:Variation in antidepressive medication response according to 5-HT2A genotype has been reported in several studies. Temperament has been proposed to be one of the vulnerability factors in mood and anxiety disorders. We studied temperament profiles of 98 patients with major depression and explored the interaction between Temperament and Character Inventory (TCI) temperament dimensions, 5-HT2A genotype (SNPs rs6311, rs6313 and rs7997012) and treatment response. No interactive effects for TCI temperament dimensions and 5-HT2A genotypes on antidepressive treatment response were found.
Keywords:
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