Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression |
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Authors: | Kadri Andre Olli Kampman Eija Setälä-Soikkeli Merja Viikki Outi Poutanen Timo Nuolivirta Nina Mononen Terho Lehtimäki Esa Leinonen Ari Illi |
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Institution: | 1. Medical School, University of Tampere, 33014, Tampere, Finland 2. P?ij?t-H?me Social and Health Care District, Lahti, Finland 5. Department of Psychiatry, Sein?joki Hospital District, Sein?joki, Finland 4. Department of Psychiatry, Kanta-H?me Central Hospital, H?meenlinna, Finland 3. Department of Psychiatry, Tampere University Hospital, Tampere, Finland 6. Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland 7. Department of Clinical Chemistry, Medical School, University of Tampere, Tampere, Finland
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Abstract: | Variation in antidepressive medication response according to 5-HT2A genotype has been reported in several studies. Temperament has been proposed to be one of the vulnerability factors in mood
and anxiety disorders. We studied temperament profiles of 98 patients with major depression and explored the interaction between
Temperament and Character Inventory (TCI) temperament dimensions, 5-HT2A genotype (SNPs rs6311, rs6313 and rs7997012) and treatment response. No interactive effects for TCI temperament dimensions
and 5-HT2A genotypes on antidepressive treatment response were found. |
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