HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory |
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| Authors: | Antonio Drago Silvia Alboni Brunello Nicoletta Diana De Ronchi Alessandro Serretti |
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| Affiliation: | (1) Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy;(2) Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy; |
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| Abstract: | Purpose Serotonin receptor 1B (HTR1B) is involved in the regulation of the serotonin system, playing different roles in specific areas of the brain. We review the characteristics of the gene coding for HTR1B, its product and the functional role of HTR1B in the neural networks involved in motivation and memory; the central role played by HTR1B in these functions is thoroughly depicted and show HTR1B to be a candidate modulator of the mnemonic and motivationally related symptoms in psychiatric illnesses. |
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