| 醋酸直肠刺激对大鼠肠道P物质、5-HT免疫阳性神经纤维的影响 |
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| 引用本文： | 陈锡强,刘可春,韩利文,王思锋,王雪,王希敏,侯海荣. 醋酸直肠刺激对大鼠肠道P物质、5-HT免疫阳性神经纤维的影响[J]. 中国实验方剂学杂志, 2008, 14(11): 71-73 |
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| 作者姓名： | 陈锡强 刘可春 韩利文 王思锋 王雪 王希敏 侯海荣 |
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| 作者单位： | 山东省科学院生物研究所,山东省科学院药物筛选研发平台,山东,济南,250014 |
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| 摘 要： | 目的:观察醋酸肠道刺激对大鼠肠道高敏感性的影响及其可能影响因子。方法:采用醋酸慢性刺激建立肠道高敏感性大鼠模型,观察大鼠肠道敏感性以及结肠黏膜下P物质、5-羟色胺免疫反应阳性纤维的变化.结果:醋酸注射直肠能够引起实验动物的腹壁撤离反射的阈值降低;肠道内的P物质含量低于对照组(P<0.01),肠道粘膜下的5-羟色胺免疫阳性神经元/神经纤维阳性指数(IOD)显著增加(P<0.01);结论:醋酸直肠慢性刺激可导致肠道高敏感性,其机制可能与引起5-HT免疫阳性神经纤维增加、P物质分泌紊乱有关。
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| 关 键 词： | 肠易激综合征 内脏高敏感性大鼠 5-羟色胺 P物质 |
| 收稿时间： | 2008-03-24 |
The Changes of Enteric Substance P and 5-HT Neurons in Rat Induced by Intrarectal Administration of Acetic Acid |
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| CHEN Xi-qiang,LIU Ke-chun,HAN Li-wen,WANG Si-feng,WANG Xue,WANG Xi-min,HOU Hai-rong. The Changes of Enteric Substance P and 5-HT Neurons in Rat Induced by Intrarectal Administration of Acetic Acid[J]. China Journal of Experimental Traditional Medical Formulae, 2008, 14(11): 71-73 |
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| Authors: | CHEN Xi-qiang LIU Ke-chun HAN Li-wen WANG Si-feng WANG Xue WANG Xi-min HOU Hai-rong |
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| Affiliation: | Biology Institute of Shandong Academy of Sciences,Jinan;Drug Screening Platform of Shandong Academy of Sciences,Jinan 250014,China |
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| Abstract: | Objective:To observe the effect and the mechanism of visceral hypersensitivity model rats.Methods:The visceral hypersensitivity model in rat was established by intrarectal administration of acetic acid.The substance P in the colon sub-mucosa layer and 5-serotoninergic neurons/fibers were observed. Results:The results suggested the acid decreased the threshold of abdominal withdrawal reflex(AWR) Model group's the substance P in the colon sub-mucosa layer decreased(P<0.01),and the positive index(IOD) of serotoninergic neurons/fibers increased significantly(P<0.01).Conclusions:Visceral |
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| Keywords: | irritable bowel syndrome visceral hypersensitivity 5-Serotonin substance P |
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