海马胶囊治疗实验性前列腺增生的研究

 目的 研究海马胶囊对实验性前列腺增生(BPH)模型的药理作用。方法 给去势大鼠肌内注射丙酸睾丸酮造成前列腺增生,同时口服给予海马胶囊,2个月后取血,测血清ACP,血清锌及前列腺腹叶NO和NOS,取器官,计算器官指数。移植16d龄胚胎鼠的尿生殖窦到成年雄性小鼠的前列腺腹叶中,造成BPH模型,给予海马胶囊1个月,测量血清ACP和血清锌水平,称器官重量。结果 大鼠BPH模型中,海马胶囊可降低前列腺腹叶和精囊腺重量;降低血清ACP和血清锌水平;升高前列腺组织NO。小鼠BPH模型中,海马胶囊可降低前列腺腹叶和背叶重量,降低血清ACP和血清Zn含量。结论 海马胶囊有明显的治疗实验性前列腺增生的作用。

Research on hippocampus capsule therapy of experimental benign prostatic hyperplasia

OBJECTIVE To study the pharmacological effects of hippocampus capsule on experimental benign prostatic hyperplasia(BPH). METHOD The rat model was made by injecting testosterone propianate (TP) to castrated rats, the mouse model was made by transplanting urogenital sinus(UGS) to the prostates of mature male mice. RESULTS In the rat BPH model, hippocampus capsule reduced the weight and index of ventral prostate, dorsal prostate and seminal vesicle, reduced the levels of serum ACP and serum Zn, and increased the NO level in ventral prostate. In the mouse BPH model, hippocampus capsule reduced the weight and index of ventral prostate and dorsal prostate, and the levels of serum ACP and serum Zn. CONCLUSION Hippocampus capsule can be used in the treatment of experimental BPH.