| 兔角膜环孢素A含量测定及其经时过程 |
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| 引用本文： | 袁成,蒋华.兔角膜环孢素A含量测定及其经时过程[J].中国临床药学杂志,1998,7(6):287-290. |
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| 作者姓名： | 袁成 蒋华 |
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| 作者单位： | [1]济南军区总医院临床药理科 [2]济南军区总医院临床眼科 |
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| 摘 要： | 目的：观察环孢素Ａ（ＣｓＡ）滴眼剂在角膜组织中的药量及经时过程，方法：１％和０．５％ＣｓＡ混悬滴眼剂５０μｌ滴入兔眼后一定时间取角膜和血样，用建立的高效液相色谱法测定含量，结果：１％和０．５％ＣｓＡ混悬滴眼剂在角膜中的药量和血药浓度基本呈倍数关系，且在滴眼后２４０ｍｉｎ内，角膜中浓度保持在２０～５２和１３～３４μｇ／ｇ达峰时间均为１２０ｍｉｎ，结论：ＣｓＡ滴眼后兔角膜中可保持较高浓度，而血液浓度很
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| 关 键 词： | 环孢素A 角膜 药物浓度 高效液相色谱 |
Determination and assaying the process of cyclosporine in rabbit cornea |
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| Yuan Cheng,Jiang Hua,Wang Jingxiang,et al Departement of Clinical Pharmacology, Departmert of Ophthalmology,General Hospital of Jinan Military Command,Jinan.Determination and assaying the process of cyclosporine in rabbit cornea[J].Chinese Journal of Clinical Pharmacy,1998,7(6):287-290. |
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| Authors: | Yuan Cheng Jiang Hua Wang Jingxiang Departement of Clinical Pharmacology Departmert of Ophthalmology General Hospital of Jinan Military Command Jinan |
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| Institution: | Yuan Cheng,Jiang Hua,Wang Jingxiang,et al 1Departement of Clinical Pharmacology,2 Departmert of Ophthalmology,General Hospital of Jinan Military Command,Jinan 250031 |
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| Abstract: | |
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| Keywords: | cyclosporine cornea drug concentration high performance liquid chromatography |
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