| 卡马西平片体外溶出度与体内吸收相关性 |
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| 引用本文： | 陈幼亭 金卫坤. 卡马西平片体外溶出度与体内吸收相关性[J]. 中国临床药学杂志, 1998, 7(2): 66-69 |
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| 作者姓名： | 陈幼亭 金卫坤 |
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| 摘 要： | 目的：考察卡马西平（ＣＢＺ）片溶出度与体内吸收的相关性。方法：应用ＺＲＳ－４溶出度仪测定卡马西平片的溶出度。４名男性健康志愿性ｐｏ单剂量２００ｍｇＣＢＺ用ＴＤｘ分析仪测定血药浓度，并按照Ｗａｇｎｅｒ－Ｎｅｌｓｏｎ公式计算药物吸收分数。结果：体外溶出度与体内药物吸收分数的相关系数ｒ＝０．９２６１，体外溶出度与体内药物吸收分数的相关系数ｒ＝０．９９７７。结论：ＣＢＺ片体外溶出度与体内吸收有较好的相关性
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| 关 键 词： | 卡马西平 体外溶出度 体内吸收 相关性 |
The correlation between dissolution in vitro and absorption in vivo of carbamazepine |
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| Chen Youting,Jin Weikun,Xia Yunyue,et al. The correlation between dissolution in vitro and absorption in vivo of carbamazepine[J]. Chinese Journal of Clinical Pharmacy, 1998, 7(2): 66-69 |
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| Authors: | Chen Youting Jin Weikun Xia Yunyue et al |
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| Abstract: | AIM: To study the correlation between dissolution in vitro and absorption in vivo of carbamazepine (CBZ)tablet. METHODS: Dissolution of CBZ tablet in vitro was tested with ZRS-4 dissolution tester. A single oral dose of 200mg CBZ tablet was given to 4 Chinese male volunteers of Han nationality. Plasma levels were determined with TDx analyzer and absorption fraction were calculated according to Wagner-Nelson's formula. RESULTS: The correlation coefficient (r) between dissolution in vitro and absorption fraction in vivo of CBZ tablet was 0. 926 1 .The correlation coefficient (r) between dissolution in vitro and logarithmic absorption fraction in vivo of CBZ tablet was 0. 997 7. CONCLUSION: There was a correlation between dissolution in vitro and absorption in vivo of CBZ. |
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| Keywords: | carbamazepine dissolution in vitro absorption in vivo correlation |
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