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| 夏枯草提取物对基质金属蛋白酶抑制作用的研究 | |
| 引用本文： | 于丽雅,蒋坤,陈阳,关威,赵树华,房学迅. 夏枯草提取物对基质金属蛋白酶抑制作用的研究[J]. 中国实验诊断学, 2009, 13(11): 1515-1517 |
| 作者姓名： | 于丽雅 蒋坤 陈阳 关威 赵树华 房学迅 |
| 作者单位： | 1. 长春中医药大学,吉林,长春,130117 2. 吉林大学分子酶学工程教育部重点实验室,吉林,长春,130023 3. 吉林大学中日联谊医院,吉林,长春,130033 |
| 摘 要： | 目的研究中药夏枯草对基质金属蛋白酶的抑制作用；探讨夏枯草的药物作用机制。方法用中药夏枯草提取液和基质金属蛋白酶-3，-13，-14和-16作用，用荧光法检测夏枯草提取液对基质金属蛋白酶活性的影响。结果夏枯草提取液抑制基质金属蛋白酶-3，-13，-14和-16的活性。结论夏枯草提取液可有效地抑制基质金属蛋白酶-3,-13，-14和-16。表明夏枯草的有效成分及其药物作用机制可能与其对基质金属蛋白酶的抑制有关。 |
| 关 键 词： | 基质金属蛋白酶 夏枯草 中药提取物 |
Spica Prunellae (Xia Ku Cao) extracts inhibit matrix metalloproteinase activities |
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| Affiliation: | YU Li-Ya, JIANG Kun, Chen Yang, et al. (1. Changchun University of Chinese Medicines, Changchun 130117, China;2. Key Laboratory for Molecular Enzymology and Enzywe Engineering of the Ministry of Education, Jilin University ;3. China-Japan Union Hospital of Jilin University) |
| Abstract: | Objective Aim Investigate whether the traditional Chinese medicinal herb Spica Prunellae inhibit matrix metalloproteinase （MMP） activity and study the mechanism of this natural product. Methods Spica Prunellae was extracted with water and other organic reagents, the MMP activities were measured with fluorescent substrate in the presence and absence of the abstracts. Results Spica Prunellae extracts can effectively inhibit the activities of MMP-3 ,-13 ,-14, and -16. Conclusion The mechanism of action of Spica Prunellae may be involved with MMP inhibition, and these findings may aid the discovery of the active ingredients in this medical herb. |
| Keywords: | Matrix Metalloproteinase （MMP） Spica Prunellae herbal extract |
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