新辅助化疗FOLFOX4方案治疗进展期胃癌的效果

目的探讨新辅助化疗奥沙利铂、氟尿嘧啶、甲酰四氢叶酸钙（FOLFOX4）方案治疗进展期胃癌的效果。方法进展期胃癌病人60例,随机分为新辅助组（30例）、手术组（30例）;新辅助组术前实施1个疗程的FOLFOX4方案化疗,化疗结束后4周行胃癌根治术,手术组直接行胃癌根治术;术后新辅助组的病人接受5个疗程FOLFOX4方案化疗,手术组接受6个疗程FOLFOX4方案化疗;对比观察两组的临床疗效及2年无瘤生存率。结果两组的根治性切除率及2年无瘤生存率比较差异均有显著性（χ2=5.45、4.02,P〈0.05）。结论新辅助化疗FOLFOX4方案能提高进展期胃癌根治性手术切除率和2年无瘤生存率。

THE EFFCTS OF NEOADJUVANT CHEMOTHERAPY PROGRAM WITH FOLFOX4 FOR ADVANCED GASTRIC CANCER

Objective To investigate the clinical efficacy of neoadjuvant chemotherapy （NC） by using FOLFOX4 for advanced gastric cancer （AGC）. Methods Sixty AGC patients were equally randomized to NC group and surgical group. To patients in NC group, one course of FOLFOX4 was given prior to surgery, and a radical gastrectomy was performed four weeks later; to those in surgical group, the operation was done without preoperative NC. Post operatively, five courses of NC were offered to patients in NC groups and six courses to those in the surgical. The therapeutic efficacy and tw9 year tumor-free survival were com pared between the two groups. Results The differences of radical resection rate and two-year tumor free survival between the two groups were significantly different （X^2= 5. 45,4.02 ;P〈0.05）. Conclusion Neoadjuvant chemotherapy applying FOLFOX4 can increase the resection rate of gastric cancer and two year survival with tumor free.