不同剂量布托啡诺治疗硬膜外麻醉后寒战临床观察

目的 观察不同剂量布托啡诺治疗硬膜外麻醉后寒战的临床效果。方法 将45例出现硬膜外麻醉后寒战病人随机分为Ⅰ、Ⅱ、Ⅲ共3组,每组15例,分别静脉注射布托啡诺0．01、0．02、0．03mg／kg,观察用药后寒战治疗效果、镇静程度、不良反应。结果 Ⅰ、Ⅱ、Ⅲ组有效率分别为60．0％、93．3％和93．3％,11组、Ⅲ组疗效显著好于Ⅰ组（uc=2．623、2．888,P〈0．01）;Ⅰ组、Ⅱ组用药后5min OAA／S评分显著高于Ⅲ组,差异均有显著意义（t=3．695、2．550,P〈0．05）;Ⅲ组不良反应发生率显著高于Ⅰ、Ⅱ组（P=0．0003）。结论 0．02mg／kg布托啡诺静脉注射适用于治疗硬膜外麻醉后寒战。

CLINICAL OBSERVATION OF THE EFFECT OF DIFFERENT DOSES OF BUTORPHANOL ON POST-EPIDURAL-ANESTHESIA SHIVERING

Objective To observe the effects of different doses of butorphanol on patients with post-epidural-anesthesia shivering （PEAS）. Methods Forty-five patients with PEAS were equally randomized to groups Ⅰ, Ⅱ and Ⅲ. They were given intravenous injection of 0.01 mg/kg, 0.02 mg/kg and 0.03 mg/kg of butorphnol, respectively. The therapeutic effect, sedation action and adverse effects were observed. Results The effective rates in groups Ⅰ, Ⅱ and Ⅲ were 20. 0%, 93.3% and 93.3%, respectively. The effectiveness of butorphanol in group Ⅱ and group Ⅲ was greater than that of group Ⅰ （uc = 2. 623, 2. 888;P〈0.01） ; The OAA/S scores five minutes after injection of the drug in group Ⅰ and group Ⅱ were significantly higher than that of group Ⅲ （t = 3. 695,2. 550;P〈0.05）. The incidence of adverse reactions in group Ⅲ was significantly higher than that in groups Ⅰ and Ⅱ （P〈0. 000 3）. Conclusion Intravenous injection of 0.02 mg/kg butorphanol is indicated for post-epi dural anesthesia shivering.