非乙醇性脂肪性肝炎病人IL-6和hsCRP测定及意义

目的探讨非乙醇性脂肪性肝炎（NASH）病人血清白细胞介素-6（IL-6）和高敏C反应蛋白（hsCRP）水平及其临床意义。方法检测27例NASH病人（NASH组）、33例非乙醇性单纯性脂肪肝病人（NAFL组）及30例健康对照者（对照组）血清IL-6、hsCRP、丙氨酸氨基转移酶（ALT）、谷氨酸氨基转移酶（AST）、γ-谷氨酰转移酶（GGT）、总胆固醇（TC）、三酰甘油（TG）和空腹血糖（FPG）水平,并测定收缩压及体质量指数（BMI）。结果与对照组相比,NASH组血清hsCRP、IL-6、ALT、AST、GGT、TC、TG、FPG、BMI和收缩压水平均明显升高,差异有显著性（F=3.58～35.70,q=5.30～10.50,P〈0.05、0.01）;NAFL组血清hsCRP、ALT、AST、GGT、TC、BMI亦明显升高,差异有显著意义（q=4.24～6.69,P〈0.01）。与NAFL组相比,NASH组血清IL-6、ALT、AST、GGT、TG、收缩压水平均明显升高,差异有显著意义（q=2.54～10.46,P〈0.05、0.01）。结论血清IL-6及hsCRP在NASH的诊断及鉴别诊断中有一定的临床意义。

DETECTIN OF IL-6 AND hsCRP IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS AND ITS SIGNIFICANCE

Objective To detect the serum interleukin-6 （IL-6） and high-sensitivity C-reaction protein （hsCRP） in patients with non-alcoholic steatohepatitis （NASH）, and assess their clinical significance. Methods Serum levels of IL-6, hsCRP, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, gamma-glutamyltranspeptidase （GGT）, total cholesterol （TC）, triglyceridelipid （TG）, and fasting blood glucose （FBP） were detected in 27 cases of NASH （NASH group）, 33 cases of non-alcoholic fatty liver （NAFL group） and 30 healthy people （control group）. Systolic blood pressure （SBP） and body mass index （BMI） were also measured. Results Compared with the control group, the NASH group showed significantly higher serum levels of hsCRP, IL-6, ALT, AST,GGT,TC,TG,FBG, and of BMI and SBP （F=3.58-35.70;q=5.30-10.50;P〈0. 05,0.01） and the NAFL group also showed significantly higher hsCRP, ALT, AST, GGT, TC, and BMI （q=4.24-6.69,P〈0.01）. The serum levels of IL-6 and ALT, AST, GGT, TG and SBP of the NASH were significantly higher opposed to those of NAFL group （q=2. 54-10. 46;P〈0. 05,0. 01）. Conclusion The serum levels of IL-6 and hsCRP have a definite clinical value in the diagnosis and differential diagnosis of NASH.