国产卡维地洛的降压疗效及对高血压患者血浆一氧化氮和内皮素的影响

目的:观察国产卡维地洛的降压疗效及其对高血压患者血浆一氧化氮(NO)、内皮素(ET)含量的影响。方法:入选80例高血压患者按随机配对原则分入卡维地洛组(卡组)及络德对照组(络组)。病人在用药前及总疗程结束后采血,用亚硝酸还原法测定血浆NO,用放射免疫技术测定血浆ET。另10例正常对照组测定血浆NO、ET。结果:降压总有效率卡组为85%,络组为84.6%,两组用药后心率均下降,两组患者降压疗效及心率下降均无显著差异(P>0.05)。用药前血NO浓度:卡组、络组的均显著低于正常对照组(P<0.05),经治疗后卡组、络组的均显著上升(P均<0.05),用药前血ET浓度:卡组、络组的均高于正常对照组(P<0.01),用药后卡组、络组的均显著下降(P均<0.05)。两药对NO、ET影响无显著差异,两药的不良反应较轻,亦无显著差异(P>0.05)。结论:两种国产卡维地洛均有较好的降压疗效。高血压病人经卡维地洛治疗后血管内皮功能有改善。

Effect of carvedilol on vascular endothelium function in essential hypertension patients

Objective:To discuss the antihypertensive effect and the influence of carvedilol on plasma endothelin(ET) and nitric oxide(NO) in essential hypertension(EH) patients.Methods:Eighty EH patients were double blind randomized assigned to two group:Carvedilol group(group A)and Luode group(group B).The plasma NO was detected by colorimeteric method,and plasma ET were detected by radio-immunoassay(RIA) method.Plasma NO and ET were also detected in 10 normal control subjects.Results:The total effective rate of Carvedilol was 85% in group A and 84.6% in group B respectively.Heart rate all declined significantly(P<0.01 all). Before treatment plasma NO in group A,B was lower than that in normal control (P<0.05 all).After treatment,plasma NO of two groups all increased significantly (P<0.05 all).Before treatment plasma ET was higher in group A,B than that of normal control (P<0.01 all).It significantly decreasesd after treatment in two groups(P<0.05 all).Side effects in group A,B was slight.Conclusion:The antihypertensive effect is similar between carvedilol and Luode groups. Carvedilol and Luode can improve the blood vessel endothelium function.