| 颅痛定对单个豚鼠心室肌细胞缺氧后复氧早期L-Ca电流的影响 |
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| 引用本文： | 曾秋棠,黄恺,祝武强,李泱,夏国谨,姚伟星. 颅痛定对单个豚鼠心室肌细胞缺氧后复氧早期L-Ca电流的影响[J]. 临床心血管病杂志, 2001, 17(5): 215-217 |
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| 作者姓名： | 曾秋棠 黄恺 祝武强 李泱 夏国谨 姚伟星 |
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| 作者单位： | 1. 华中科技大学同济医学院心血管病研究所华中科技大学同济医学院附属协和医院心导管室,
2. 华中科技大学同济医学院药理学教研室 |
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| 基金项目： | 卫生部青年科研基金!资助 (No.96 Q- 2 5) |
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| 摘 要： | 目的 :研究颅痛定 (左旋四氢巴马汀 ,L - tetrahy- dropalm atine,L - THP)对缺氧后复氧早期心室肌细胞 L - Ca电流的影响。方法 :使用全细胞膜片钳技术研究心室肌细胞 L - Ca电流的变化。结果 :经 2 0 m in的缺氧以及 5 min的复氧后 ,1,10 ,10 0 (μmol· L- 1 ) L - THP分别将 Ca- max电流从 (6 75 .75± 10 7.0 7) p A减少至 (6 45 .46±10 8.75 ) p A、(4 92 .0 8± 72 .84) p A、(376 .6 0± 71.35 ) p A ,P值分别为 >0 .0 5、<0 .0 5、<0 .0 1。结论 :L - THP能有效地减少缺氧后复氧早期心室肌细胞 L - Ca电流 ,这种作用无疑是其抗再灌注早期心律失常的电生理基础。
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| 关 键 词： | 左旋四氢巴马汀 心肌再灌注 L型钙通道 |
| 文章编号： | 1001-1439(2001)05-0215-03 |
| 修稿时间： | 2000-08-09 |
The effect of L-tetrahydropalmatine on L-Ca current in single ventricular myocyte of guinea pig during early reoxygenation |
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| ZENG Qiutang HUANG Kai ZHU Wuqiang LI Yang XIA Guojin YAO Weixing. The effect of L-tetrahydropalmatine on L-Ca current in single ventricular myocyte of guinea pig during early reoxygenation[J]. Journal of Clinical Cardiology, 2001, 17(5): 215-217 |
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| Authors: | ZENG Qiutang HUANG Kai ZHU Wuqiang LI Yang XIA Guojin YAO Weixing |
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| Affiliation: | ZENG Qiutang 1 HUANG Kai 1 ZHU Wuqiang 1 LI Yang 2 XIA Guojin 2 YAO Weixing 2 |
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| Abstract: | Objective:To investigate the effect of L-tetrahydropalmatine onL-Ca current in single ventricular myocyte of guinea pig during early reoxygenation. Method:The whole cell patch clamp technique was used to study the change of L-Ca current. Result:After 20 min deoxygenation and 5 min reoxygenation, L-tetrahydropalmatine reduced the I Ca-max from (675.75±107.07)pA to (645.46±108.75) pA(P＞0.05, n=6),(492.08±72.84) pA(P＜0.05, n=6), (376.60±71.35) pA(P＜0.01, n=6)respectly. Conclusion:L-tetrahydropalmatine can significantly reduce the L-Ca current during early reoxygenation, which may contribute to its effect of anti-reperfusion arrhythmia. |
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| Keywords: | L tetrahydropalmatine Myocardial reperfusion L Ca current |
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