抑肽酶治疗脑出血脑水肿临床分析

目的:探讨抑肽酶治疗脑出血脑水肿的作用机制。方法:92例高血压脑出血病例随机分为治疗组与对照组。对照组给予20%甘露醇常规减轻脑水肿治疗,治疗组在对照组治疗基础上加用抑肽酶,观察2组疗效和血肿吸收情况。结果:治疗组基本治愈率为77%,明显高于对照组的45%(P<0·05);治疗组各部位血肿全部吸收率为69%,明显优于对照组的45%(P<0·05)。结论:抑肽酶通过对激肽释放酶和激肽级联系统的抑制作用,减少凝血酶的产生和对血肿局部凝血酶的拮抗作用,从而达到促进水肿和血肿吸收作用。

Aprotinin for Cerebral Hemorrhage and Cerebral Edema :Clinical Analysis

OBJECTIVE:To discuss the action mechanism of aprotinin in the treatment of hemorrhage and edema of brain.METHODS:A total of 92 patients with hypertensive cerebral hemorrhage were randomly divided into control group and trial group:the control group was treated with 20% manicol as a routine therapy for the management of cerebral edema,while the trial group was treated with 20% manicol plus aprotinin.The curative effects and hematoma absorption condition of two groups were observed.RESULTS:The basic cure rate was 77%,significantly higher than in the control group(45%)(P<0.05).The fully absorption rate of hematoma in the trial group was 69%,significantly higher than in the control group(45%)(P<0.05).CONCLUSION:The mechanism of aprotinin in promoting the absorption of hematoma and edema maybe attributed to its inhibition on the kallikrein and kinin cascade system,which may lead to the reduction of the production of thrombin and the antagonistic action on the local thrombin of hematoma.