EFFECT OF DIPYRIDAMOLE ON BLOOD GLUCOSE AND LIVER CYCLIC AMP LEVELS AND PLATELET COUNT DURING ENDOTOXAEMIA IN MICE |
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| Authors: | Layla M. Al-Jibouri Rafid A. Najim |
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| Affiliation: | Department of Pharmacology, College of Medicine, Baghdad University, Iraq. |
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| Abstract: | 1. Blood glucose, liver cyclic AMP (cAMP) levels, and platelet count were studied at different times during a 12 h interval after intravenous (i.v.) endotoxin injection (40 mg/kg) in mice. 2. Blood glucose and liver cAMP levels showed a progressive decrease in endotoxic mice and the decrease was significant after 8 and 12 h. 3. Dipyridamole (50 mg/kg) administered intraperitoneally (i.p.) 7 h post-endotoxin improved blood glucose and liver cAMP levels. 4. Platelet counts were decreased after 1 h in endotoxic mice and remained decreased up to 8 h. Dipyridamole administered soon after endotoxin improved platelet counts in endotoxic mice and increased survival rate to 100%. |
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| Keywords: | blood glucose cyclic AMP dipyridamole endotoxaemia platelet |
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