慢性肾功能衰竭病人经血液透析后红细胞变形能力的改变

文中对慢性肾功能衰竭病人及经血液透析治疗后的红细胞变形能力进行了测定。结果表明：与正常红细胞的椭园形衍射环相比，慢性肾衰病人红细胞的衍射环长轴明显缩短，短轴明显增宽，形成一个橄榄形。经过血液透析后红细胞的衍射环有明显改善，趋于正常。提示肾衰后硬化红细胞数量明显增多，红细胞变形能力及红细胞膜的稳定性明显降低。这些改变与机体长期处于酸中毒、水和电解质紊乱、内毒素增加及ＳＯＤ水平增高等环境有密切关系，可导致和加重肾脏微循环障碍。血液透析可有效地改善红细胞的变形能力。

CHANGES OF ERYTHROCYTE DEFORMABILITY IN CHRONIC RENAL FAILURE WITH HEMODIALYSIS TREATMENT

The erythrocyte deformability was compared between the healthy control group (n = 17), petient group with chronic renal fallure (CRF. n=17) and treated group with hemodialysis (n = 28). The long axis of the erythrocyte diffraction ring in CRF group was singnificantly shorter than that in controls (p<0.001), while the short axls was sisnificantly wider (p<0.001), The diffrac- tion figure in CRF group looked like an olive. After a period of hemodislysis treatment, the diffraction figure became better (p<0.001) and close to sclerous erythrocyte was increaed in CRF group, the deformability and membrane stability of erythrocyte in CRF were significantly lower than those in controls. These changes were possibly attributted to the condition of acidosis, water-electreolyte im- balance and the increase of endotoxin and SOD. The abnormality of the hemorheological properties of the erythrocyte will lead to and exacerbate the renal microcirculatory disturbance. Hemodialysis would improve the erythrocyte deformability effectively.