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增殖细胞核抗原和P27在前列腺癌中的表达及临床意义
引用本文:秦维香,张晓艳,刘东举,谢成耀. 增殖细胞核抗原和P27在前列腺癌中的表达及临床意义[J]. 中国医院用药评价与分析, 2007, 7(1): 50-52
作者姓名:秦维香  张晓艳  刘东举  谢成耀
作者单位:1. 沈阳市第五人民医院、沈阳市肿瘤医院病理科,沈阳市,110023
2. 中国医科大学病理教研室,沈阳市,110001
摘    要:目的:探讨增殖细胞核抗原(PCNA)和P27蛋白在前列腺癌中的表达及临床意义。方法:应用免疫组化S-P方法检测30例前列腺增生和46例前列腺癌中的PCNA、P27蛋白的表达。结果:前列腺增生组织中的PCNA强阳性表达率为6.7%,前列腺癌强阳性表达率为82.6%,两者比较有显著的差异(P<0.01)。PCNA的强阳性表达率与前列腺癌的分化程度呈负相关(P<0.05〉,与临床分期呈正相关(P<0.05)。前列腺增生组织中P27蛋白的强阳性表达率为70%,前列腺癌中的表达率为17.4%,两者比较有显著差异(P<0.01),P27蛋白的表达与前列腺癌组的分化程度呈正相关(P<0.05〉,与临床分期呈负相关(P<0.05),在前列腺增生组织及前列腺癌中PCNA与P27蛋白表达呈负相关(P<0.05)。结论:同时检测P27、PCNA对前列腺癌的预测,恶性程度的判定,预后的估计有重要指导意义。

关 键 词:增殖细胞核抗原  P27蛋白  前列腺癌  免疫组化
文章编号:1672-2124(2007)01-0050-03
修稿时间:2006-10-24

Expression of PCNA and P27 in Prostate Carcinoma and Its Clinical Significance
QIN Weixiang,ZHANG Xiaoyan,LIU Dongju,XIE Chengyao. Expression of PCNA and P27 in Prostate Carcinoma and Its Clinical Significance[J]. Evaluation and Analysis of Drug-Use in Hospital of China, 2007, 7(1): 50-52
Authors:QIN Weixiang  ZHANG Xiaoyan  LIU Dongju  XIE Chengyao
Abstract:OBJECTIVE:To study the expression of PCNA and P27 protein in patients with prostate carcinoma and to study its clinical significance. METHODS: The expressions PCNA and P27 in 30 patients with hyperplasia of prostate gland and 46 with prostate carcinoma were detected by S-P immunohistochemical method. RESULTS: Strong positive expression rates of PCNA in patients with hyperplasia of prostate gland and in those with prostate carcinoma were 6.7% and 82.6%, respectively, and there were significant differences between 2 groups (P<0.01). The strong positive expression of PCNA showed a negative correlation with differentiation degree of prostatic carcinoma (P<0.05) but a positive correlation with its clinical stage (P<0.05). Strong positive expression rates of P27 in patients with hyperplasia of prostate were 70%, and 17.4% in those with prostate carcinoma, and there were significant differences between 2 groups (P<0.01). The expression of P27 showed a positive correlation with differentiation degree of prostatic carcinoma (P<0.05), but a negative correlation with clinical stage (P<0.05). A negative correlation was found between P27 and PCNA expressions in both hyperplasia of prostate gland and prostate carcinoma (P<0.05). CONCLUSION: It is of great significance to determine P27 and PCNA for the diagnosis, malignant grading and prognostic estimation of prostate carcinoma.
Keywords:proliferating cell nuclear antigen (PCNA)  p27protein  prostate carcinoma  immunohistochemistry
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