血管内大B细胞淋巴瘤临床病理学特征分析

目的探讨血管内大B细胞淋巴瘤的临床病理学特征。 方法回顾性分析2008年1月至2017年12月经泰安市中心医院病理科确诊的12例血管内大B细胞淋巴瘤患者的临床资料，观察血管内大B细胞淋巴瘤的病理形态学特征及免疫表型。 结果12例血管内大B细胞淋巴瘤患者中男性7例，女性5例，年龄58~76岁；临床症状主要有皮肤红斑及皮下结节（发生于皮肤者）、头痛头晕及行走不稳（发生于中枢神经系统者）咳嗽咳痰（发生于肺者）；光镜下表现血管腔内充满肿瘤细胞，肿瘤细胞大多相似于中心母细胞或免疫母细胞；免疫组织化学检测显示肿瘤细胞CD20阳性。 结论血管内大B细胞淋巴瘤是一种相对少见的淋巴瘤，以淋巴瘤细胞选择性的在血管腔内生长为特征；临床表现与其发生部位有关，掌握其共同的特征并结合免疫组织化学检测结果方能正确诊断。

Clinicopathological features of intravascular large B-cell lymphoma

ObjectiveTo summarize the clinicopathological features of intravascular large B-cell lymphoma (IVLBCL). MethodsA retrospective analysis was performed on the clinical data of 12 cases of IVLBCL definitely diagnosed at the Department of Pathology, Tai′an Central Hospital from January 2008 to December 2017. Hematoxylin and eosin staining, immunohistochemistry, and histochemistry were performed on the archival paraffin sections. ResultsAmongst the 12 patients studied, 7 were male and 5 was female. Their age at the time of operation ranged from 58 to 76 years. The main clinical symptoms were skin erythema and subcutaneous nodules (in the skin), headache, dizziness and walking instability (in the central nervous system), and cough and phlegm (in the lung). Microscopically, the vascular lumen was filled with tumor cells. Most tumor cells were similar to centroblasts or immunobcasts. Immunohistochemistry showed positive CD20 staining in tumor cells. ConclusionIVLBCL is a relatively rare lymphoma characterized by selective growth of lymphoma cells in the vascular lumen. The clinical manifestation is related to the site of occurrence. A thorough understanding of the associated clinical features and immunohistochemical results is helpful in arriving at the correct diagnosis.