Flavonoids from Dalbergia louvelii and their antiplasmodial activity |
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Authors: | Beldjoudi Naïma Mambu Lengo Labaïed Mehdi Grellier Philippe Ramanitrahasimbola David Rasoanaivo Philippe Martin Marie Thérèse Frappier François |
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Affiliation: | USM 0502-UMR 8041CNRS Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, 63 Rue Buffon, 75231 Paris Cedex 05, France. |
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Abstract: | Four new flavonoids (1-4), along with 13 known compounds, were isolated from the heartwood of Dalbergia louvelii by following their potential to inhibit in vitro the growth of Plasmodium falciparum. Of the isolated compounds, four known compounds showed antiplasmodial activity with IC(50) values ranging from 5.8 to 8.7 microM, namely, (R)-4' '-methoxydalbergione (5), obtusafuran (6), 7,4'-dihydroxy-3'-methoxyisoflavone (7), and isoliquiritigenin (8). The structures of the new compounds were determined using spectroscopic techniques as 1-(3-hydroxyphenyl)-3-(4-hydroxy-2,5-dimethoxyphenyl)propane (1), spirolouveline (2), (3R)-7,2'-dihydroxy-4',5'-dimethoxyisoflavanone (3), and 3-(2,4-dihydroxy-5-methoxy)phenyl-7-hydroxycoumarin (4), respectively. |
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