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| 常用乳腺癌化疗方案与ER、PR及C-erbB-2表达的相关性 | |
| 引用本文： | 张晓丽,邵雪辉,杨翠军,温玉梅,冯丹,张鑫雨,李鑫.常用乳腺癌化疗方案与ER、PR及C-erbB-2表达的相关性[J].江苏医药,2011,37(4). |
| 作者姓名： | 张晓丽 邵雪辉 杨翠军 温玉梅 冯丹 张鑫雨 李鑫 |
| 作者单位： | 1. 河北北方学院实验中心电镜室,河北省张家口市,075029 2. 张家口市第二人民医院内科 3. 河北北方学院大学生科协 |
| 基金项目： | 张家口市科技局课题(NO:0801021D) |
| 摘 要： | 目的研究乳腺癌细胞对我院临床常用三种化疗方案1.环磷酰胺+阿霉素+5-氟尿嘧啶(CAF);2.紫杉醇+阿霉素(TA);3.环磷酰胺+甲氨蝶呤+5-氟尿嘧啶(CMF)]的敏感性及其与雌激素受体(ER)、孕激素受体(PR)和癌基因C-erbB-2的相关性。方法利用细胞原代培养和MTT法观察CAF,TA,CMF方案对乳腺癌原代细胞培养的抑制率,运用链霉菌抗生物素蛋白-过氧化物酶连结免疫组织化学方法检测ER、PR、C-erbB-2的基因表达情况。结果乳腺癌细胞对3组化疗药物敏感率不同,CAF>TA>CMF,但差异无统计学意义(P>0.05);C-erbB-2在小于40岁组阳性率高于大于51岁组(P<0.05)。ER、PR和C-erbB-2阳性表达率分别为68.5%、54.0%和63.7%,且与药敏检测有相关性。结论在进行乳腺癌药敏实验的同时,建议检测ER、PR和C-erbB-2,以便对乳腺癌采用更有效的治疗方法。 |
| 关 键 词： | 乳腺癌 药敏实验 雌激素受体 孕激素受体 C-erbB-2 |
The correlation between expressions of ER,PR,C-erbB-2 and commonly used regime in treating breast carcinoma |
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| ZHANG Xiaoli,SHAO Xuehui,YANG Cuijun,et al..The correlation between expressions of ER,PR,C-erbB-2 and commonly used regime in treating breast carcinoma[J].Jiangsu Medical Journal,2011,37(4). | |
| Authors: | ZHANG Xiaoli SHAO Xuehui YANG Cuijun |
| Institution: | ZHANG Xiaoli,SHAO Xuehui,YANG Cuijun,et al.Department of Central Laboratory,Hebei North University,Zhangjiakou 075000,CHINA |
| Abstract: | Objective To study the efficacy of three regimes of commonly used chemotherapy (cyclophosphamide+adriamycin+5-fluorouracil(CAF),paclitaxel+adriamycin(TA),cyclophosphamide+methotrexate+5-fluorouracil(CMF)] and their relation with estrogen receptor(ER),progesterone receptor(PR) and C-erbB-2 for breast carcinoma cell.Methods The inhibition rates of CAF,TA and CMF on primary cultured breast carcinoma cells were observed by MTT method.The expressions of ER,PR and C-erbB-2 were examined with streptavidin-perosid... |
| Keywords: | Breast carcinoma Susceptibility test for drug Estrogen receptor Progesterone receptor C-erbB-2 |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |