| 咪达唑仑对七氟烷镇痛和催眠作用的影响 |
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| 引用本文： | 王雷,廖艺聪,李艳,曹俊平.咪达唑仑对七氟烷镇痛和催眠作用的影响[J].江苏医药,2011,37(7). |
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| 作者姓名： | 王雷 廖艺聪 李艳 曹俊平 |
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| 作者单位： | 徐州医学院麻醉学院,221002 |
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| 基金项目： | 国家自然科学基金(30900417) |
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| 摘 要： | 目的观察咪达唑仑对七氟烷镇痛和催眠作用的影响。方法将40只小鼠随机均分成四组:生理盐水(NS)组、咪唑安定+NS组(M组)、NS+七氟烷组(S组)和咪达唑仑+七氟烷组(MS组)。实验方法:咪达唑仑2.7 mg/kg腹腔注射;甩尾法、催眠实验中分别腹腔注射七氟烷2.1、3.8 ml/kg;扭体法实验中皮下注射七氟烷3.0 ml/kg。甩尾法记录小鼠尾巴自进入水中到甩出水面的时间(甩尾潜伏期,TFL);扭体法观察小鼠腹腔注射1%冰醋酸0.1 ml/10 g后,15 min内的扭体次数;催眠实验记录小鼠翻正反射消失至恢复的时间(睡眠时间)。结果与NS组比较,S组、MS组TFL和睡眠时间延长,扭体次数减少(P<0.05);与S组比较,MS组TFL和睡眠时间明显延长,扭体次数减少(P<0.05)。结论咪达唑仑可增强七氟烷的镇痛及催眠效应。
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| 关 键 词： | 咪达唑仑 七氟烷 镇痛 催眠 |
Effect of midazolam on sevoflurane-induced analgesia and hypnosis in mice |
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| WANG Lei,LIAO Yicong,LI Yan,et al..Effect of midazolam on sevoflurane-induced analgesia and hypnosis in mice[J].Jiangsu Medical Journal,2011,37(7). |
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| Authors: | WANG Lei LIAO Yicong LI Yan |
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| Institution: | WANG Lei,LIAO Yicong,LI Yan,et al.Department of Anesthesiology,Xuzhou Medical College,Xuzhou 221002,CHINA |
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| Abstract: | Objective To observe the effects of midazolam on sevoflurane-induced analgesia and hypnosis in mice.Methods Forty mice were randomly and equally divided into four groups of normal saline(NS),M(midazolam+NS),S(NS+sevoflurane) and MS(midazolam+sevoflurane).Midazolam 2.7 mg/kg was intraperitoneally injected in all tests.Sevoflurane in the doses of 2.1 ml/kg and 3.8 ml/kg was intraperitoneally injected in tail-flick test and hypnosis test,respectively.Sevoflurane 3.0 ml/kg was hypodermically given in twisting t... |
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| Keywords: | Midazolam Sevoflurane Analgesia Hypnosis |
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