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| 瞬时感受器电位香草酸受体1对异氟烷镇痛和催眠作用的影响 | |
| 引用本文： | 张明阳,刘亚君,周美艳,陈晏,蔡慧明,宋苏沛,邵东华,杭黎华,戴体俊.瞬时感受器电位香草酸受体1对异氟烷镇痛和催眠作用的影响[J].江苏医药,2011,37(7). |
| 作者姓名： | 张明阳 刘亚君 周美艳 陈晏 蔡慧明 宋苏沛 邵东华 杭黎华 戴体俊 |
| 作者单位： | 1. 徐州医学院江苏省麻醉学重点实验室,221002 2. 徐州医学院药学院,221002 3. 镇江市第一人民医院麻醉科 4. 徐州医学院麻醉药理学教研室,221002 |
| 基金项目： | 国家自然科学基金资助项目(30872432、30471657、39970715); 江苏省自然科学基金资助项目(BK200143) |
| 摘 要： | 目的探讨瞬时感受器电位香草酸受体1(TRPV1)对异氟烷镇痛及催眠作用的影响。方法在热板法和扭体法镇痛实验中,80只小鼠随机均分为生理盐水(NS组)和异氟烷(异氟烷组,腹腔注射异氟烷1.0 ml/kg)两组;随后各组再均分为4个亚组,分别注射溶媒、辣椒素(125、250、500ng/kg)。记录热板法热板痛阈(HPPT)和扭体法扭体次数。催眠实验中,异氟烷组小鼠腹腔注射异氟烷1.0 ml/kg后,侧脑室注射溶媒、辣椒素(125、250、500 ng/kg),记录给药后小鼠的睡眠时间(ST)。结果与异氟烷+溶媒亚组相比,其余3个异氟烷+辣椒素亚组HPPT降低(P<0.05)、扭体次数增加(P<0.01),但ST无明显变化(P>0.05)。结论 TRPV1可能是异氟烷抗热刺激痛和内脏化学刺激痛的靶位之一,但与异氟烷的催眠作用关系不大。 |
| 关 键 词： | 异氟烷 镇痛 催眠 瞬时感受器电位香草酸受体1 |
Effects of transient receptor potential vanilloid 1 on isofurane-induced analgesia and hypnosis |
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| ZHANG Mingyang,LIU Yajun,ZHOU Meiyan,et al..Effects of transient receptor potential vanilloid 1 on isofurane-induced analgesia and hypnosis[J].Jiangsu Medical Journal,2011,37(7). | |
| Authors: | ZHANG Mingyang LIU Yajun ZHOU Meiyan |
| Institution: | ZHANG Mingyang,LIU Yajun,ZHOU Meiyan,et al.Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical College,Xuzhou 221002,CHINA |
| Abstract: | Objective To investigate the effects of transient receptor potential vanilloid 1(TRPV1) on isofurane-induced analgesia and hypnosis.Methods In hot-plate test and twisting test,eighty mice were randomly and equally divided into two groups of normal saline(NS) and isofurane,which then were respectively injected with solvent,capsaicin 125,250 and 500 ng/kg(10 mice in each subgroup).The pain threshold in hot-plate test(HPPT) and the times of body twisting in twisting test were recorded,respectively.In hypnosis ... |
| Keywords: | Isoflurane Analgesia Hopnosis Transient receptor potential vanilloid 1 |
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