| 血清脂联素水平与2型糖尿病患者动脉粥样硬化的相关性 |
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| 引用本文： | 王雪琴,马向华,沈捷,金艳,陈金锋,吴刚,苏建彬,徐峰,高丹,王晓华.血清脂联素水平与2型糖尿病患者动脉粥样硬化的相关性[J].江苏医药,2011,37(3). |
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| 作者姓名： | 王雪琴 马向华 沈捷 金艳 陈金锋 吴刚 苏建彬 徐峰 高丹 王晓华 |
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| 作者单位： | 1. 南通大学第二附属医院内分泌病科,226001
2. 南京医科大学第一附属医院内分泌病科 |
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| 基金项目： | 南通市社会发展科技计划项目(S2009024); 江苏省“六大人才高峰”第六批资助项目 |
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| 摘 要： | 目的探讨脂联素(APN)与2型糖尿病(T2DM)动脉粥样硬化的相关性。方法采用ELISA法检测T2DM动脉粥样硬化病变组(AS组,60例)、T2DM非动脉粥样硬化病变组(NAS组,96例)和正常对照组(NC组,68例)血清APN水平。同时检测糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并计算体重指数(BMI)和胰岛素抵抗指数(HOMA-IR)。结果 APN在NC组、NAS组、AS组依次减低(P<0.05);AS组和NAS组APN水平与BMI、HOMA-IR、HbAl呈负相关(r值分别为-0.467、-0.444、-0.168)(P<0.05),与HDL-C正相关(r值为0.176)(P<0.05);APN、HOMA-IR与HbAlc是DM患者动脉粥样硬化发生的独立危险因素。结论 APN是DM患者动脉粥样硬化发生的独立危险因素,有可能是治疗T2DM大血管并发症的新靶点。
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| 关 键 词： | 脂联素 动脉粥样硬化 2型糖尿病 |
Correlation between adiponectin level and atherosclerosis in type 2 diabetic patients |
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| WANG Xueqin,MA Xianghua,SHEN Jie,et al..Correlation between adiponectin level and atherosclerosis in type 2 diabetic patients[J].Jiangsu Medical Journal,2011,37(3). |
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| Authors: | WANG Xueqin MA Xianghua SHEN Jie |
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| Institution: | WANG Xueqin,MA Xianghua,SHEN Jie,et al.Department of Endocrinology,Second Affiliated Hospital,Nantong University,Nantong 226001,CHINA |
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| Abstract: | Objective To analyze the relationship between adiponectin(APN) and atherosclerosis in type 2 diabetes mellitus(T2DM).Methods Lipid profile(TC,TG,HDL-C,LDL-C),glycosylated hemoglobin A1c(HbA1c) and APN(ELISA method) were detected in 60 T2DM cases with atherosclerosis (group AS),96 T2DM cases without atherosclerosis(group NAS) and 68 normal controls (group NC).Body mass index(BMI) and insulin resistance indice(HOMA-IR) were calculated as well.Results APN was decreased in an order of NC
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| Keywords: | Adiponectin Atherosclerosis Type 2 diabetes mellitus |
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