Immunomodulatory effects and structure-activity relationship of botanical pentacyclic triterpenes: A review |
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Authors: | Nurul Hikmah Harun Abdi Wira Septama Wan Amir Nizam Wan Ahmad Rapeah Suppiana |
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Institution: | 1. School of Health Sciences, Heath Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia;2. School of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Nerus 21300, Malaysia;3. Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan Puspitek Serpong, Tangerang Selatan 15314, Indonesia |
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Abstract: | Botanical pentacyclic triterpenes possessed a broad range of pharmacological activities such as antioxidant, anti-tumor, anti-microbial and anti-inflammatory activities. It is believed that the mechanisms involved in these bioactivities are due to the modulation of immune system. Recently, the pharmacological validation on immunomodulatory of pentacyclic triterpenes derived from higher plants is very limited and several existence review papers related for this group of compound have not been focused for this activity. In this review, we have highlighted several studies on immunomodulatory potential of botanical pentacyclic triterpenes isolated from wide array of different species of medicinal plants and herbs based on various preclinical in vitro and animal models. This review also attempts to discuss on bioactivities of compouns related with their structure-activity relationship. Hence, the evaluation of pentacyclic triterpenes offers a great opportunity to discover adjuvants and novel therapeutic agents that presented beneficial immunomodulatory properties. |
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Keywords: | botanical immunomodulatory pentacyclic triterpenes structure activity relationship |
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