鱼鳞病患者鳞屑、皮肤和血液的胆固醇和胆固醇硫酸酯分析

目的：探讨脂质与鳞屑性疾病的关系。方法：用气相质谱方法对性联隐性鱼鳞病（ＲＸＬＩ）、寻常性鱼鳞病（ＩＶ）各５例和５例正常对照组的鳞屑、表皮、真皮和血液中的胆固醇硫酸酯（ＣＳ）和胆固醇（ＣＨ）进行了定量分析。结果：鳞屑中ＲＸＬＩ组ＣＳ含量显著高于ＩＶ和正常对照组，ＣＨ和ＣＨ／ＣＳ显著低于其他二组。在表皮、真皮和血液中，ＲＸＬＩ组ＣＳ含量显著增高，而ＣＨ含量无明显变化，ＣＨ／ＣＳ下降。结论：ＲＸＬＩ的鳞屑产生与ＣＳ积聚及ＣＨ／ＣＳ下降有关，而ＩＶ的发病则与ＣＳ和ＣＨ无关。

Lipid analysis of cholesterol and cholesterol sulfate in scaling,skin, and blood of ichthyosis patients.

Objective:In order to investigate the relationship between lipids metabolism and scaling diseases.Method:We quantitatively detected the cholesterol sulfate and cholesterol in scaling,epidermal,dermal and serum of 5 recessive X linked ichthyosis (RXLI),5 ichthyosis vulgaris (IV) and 5 normal controls respectively by gas chromatography mass spectrum (GC MS).Results:The value of cholesterol sulfate significant higher in RXLI group than that in IV and normal group,scaling cholesterol and the ratio of cholesterol to cholesterol sulfate significantly decreased in RXLI group than in that of other two groups.In RXLI group,cholesterol sulfate increased and the ratio of chlesterol to cholesterol sulfate decreased significantly in epidermal,dermal and serum.Conclusion:The cholesterol sulfate accmulation accomparnied by cholesterol reduction account for the main mechanism of scal in RXLI,and the pathogenesis of IV was not related to the content of cholesterol sulfate and cholesterol.