银屑病患者皮损内及血中神经肽(SP、SS)的研究

应用放射免疫分析法（ＲＩＡ）对４０例寻常性银屑病病人血及皮损中的Ｐ物质（ＳＰ）、生长抑素（ＳＳ）进行了测定，发现进行期和静止期银屑病病人皮损中ＳＰ增高，与正常人相比差异有显著性意义。ＳＰ血浆中含量、ＳＳ血及皮损中含量均与正常人无显著差别。结果提示：ＳＰ可能通过局部作用参与银屑病的病理过程，ＳＳ可能对银屑病的病理改变无影响。这也提示有必要开发安全、可靠的ＳＰ拮抗剂来治疗银屑病。

Study of Substance P and Somatostatin Levels in Lesions and Seruml of Psoriasis.

In this investigation,the levels of substance P(SP) and Somatostatin (SS) in Plasma and skin lesions of 40 psoriasis vulgaris patients and that of 30 normal persons were measured by radioimmunoassay(RIA).The content of SP in lesions of active and stable psoriasis increased significantly comparing with that in recovery patients and normal cases(P<0.05).Sp and SS levels in Plasma and skin lesions had no notable difference between two groups (P>0.05).All these suggested SP may participate the histopathologic process of psoriasis locally.It was probably a major factor in the occurance development and maintenance of psoriasis lesions.We can be infered to study utilize more safe and effective SP antagonist to treat Psoriasis.