| p53 p21和PCNA在寻常疣中的过度表达 |
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| 引用本文： | 徐兵,涂平.p53 p21和PCNA在寻常疣中的过度表达[J].中国皮肤性病学杂志,1998,12(6):323-325. |
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| 作者姓名： | 徐兵 涂平 |
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| 作者单位： | 北京医科大学第一医院皮肤科，青岛医学院附属第二医院皮肤科，北京医科大学第一医院皮肤科 |
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| 基金项目： | 国家教委青年归国人员基金,西安杨森皮肤科学教育研究基金 |
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| 摘 要： | 目的：研究寻常疣ｐ５３蛋白、ｐ２１蛋白和增殖细胞核抗原（ＰＣＮＡ）过度表达与人类乳头瘤病毒（ＨＰＶ）感染的关系。方法：采用免疫组化方法对石蜡包埋组织标本进行检测。结果：１５例寻常疣皮损中ｐ５３、ｐ２１以及ＰＣＮＡ阳性标本分别为６例（４０％）、５例（３３％）和９例（６６％）。ｐ５３阳性细胞多位于基底层，ｐ２１阳性细胞则多分布于棘细胞层的中下层，ＰＣＮＡ阳性细胞散在分布于整个增生的表皮。受ＨＰＶ感染的空泡样变性细胞核中均有ｐ５３、ｐ２１以及ＰＣＮＡ过度表达者４例。结论：证实了寻常疣中存在ｐ５３、ｐ２１和ＰＣＮＡ过度表达，并从原位上找到ＨＰＶ感染与ｐ５３、ｐ２１过度表达和细胞异常增生相关联的细胞学证据。
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| 关 键 词： | 寻常疣 乳头状瘤病毒.人 p~(53)蛋白 p~(21)蛋白 增殖细胞核抗原 |
Over-expression of p53,p21 and PCNA in common warts. |
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| Xu Bing,Tu Ping,Ma Shengqing,et al..Over-expression of p53,p21 and PCNA in common warts.[J].The Chinese Journal of Dermatovenereology,1998,12(6):323-325. |
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| Authors: | Xu Bing Tu Ping Ma Shengqing |
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| Institution: | Xu Bing,Tu Ping,Ma Shengqing,et al.Department of Dermatology,First Hospital,Beijing Medical University,Beijing,100034 |
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| Abstract: | Objective:To study the relation between the expression of p53,p21,proliferating cell nuclear antigens(PCNA) and the infection of human papillomavirus(HPV).Methods:Samples from 15 cases of common warts tissue were detected by immunohistochemical staining.Results:p53,p21 and PCNA positive staining were 6(40%),5(33%),and 9(66%) respectively.The majority of p53-positive keratinocytes located in the epidermal basal layer,p21 positive staining in the superbasal layer,and PCNA reactivity scattered throughout the proliferated epidermis.Positive staining of p53,p21 and PCNA in some vacolated keratiocytes in 4 cases.Conclusion:Our finding inferred that HPV might regulate the induction of wild type p53 overexpression,as well as p21 and PCNA over expression in keratinocytes. |
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| Keywords: | Common wart HPV p53 protein p21 protein PCNA |
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