| 肝细胞癌患者血清ECM1、MMP-9和VEGF水平的变化及其意义 |
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| 引用本文： | 陈浩,李建生,荚卫东,王伟,许戈良,马金良. 肝细胞癌患者血清ECM1、MMP-9和VEGF水平的变化及其意义[J]. 实用肝脏病杂志, 2010, 13(6): 424-427. DOI: 10.3969/j.issn.1672-5069.2010.06.009 |
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| 作者姓名： | 陈浩 李建生 荚卫东 王伟 许戈良 马金良 |
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| 作者单位： | 安徽医科大学附属省立医院肝脏外科,合肥市230001 |
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| 基金项目： | 国家自然科学基金项目，安徽省高等学校省级自然科学研究项目，安徽省自然科学基金项目，安徽省优秀青年科技基金项目，安徽省"115"产业创新团队项目 |
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| 摘 要： | 目的检测肝细胞癌患者血清ECM1水平,分析其与MMP-9和VEGF水平间的关系。方法应用酶联免疫吸附法测定40例肝癌患者血清ECM1、MMP-9和VEGF水平,分析其与肿瘤临床与病理特征间的关系。结果 40例肝癌患者血清ECM1、MMP-9和VEGF平均水平分别为150.01±5.85pg/ml、467±30.81μg/l和751.29±51.08pg/ml;三者水平均与肿瘤包膜、TNM分级、发生淋巴结转移和肿瘤分期有关(P0.005),而ECM1和VEGF还与血管侵犯有关(P0.005);ECM1与MMP-9和VEGF水平呈显著正相关(r=0.438,P=0.005r;=0.427,P=0.006)。结论 ECM1可能通过与MMP-9和VEGF相互作用而促进了肝癌血管生成和侵袭转移。
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| 关 键 词： | 肝细胞癌 细胞外基质蛋白-1 血管内皮生长因子 基质金属蛋白酶-9 |
Serum levels of extracellular matrix protein 1,MMP-9 and VEGF in patients with hepatocellular carcinoma |
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| Affiliation: | CHEN Hao,LI Jiansheng,JIA Weidong,et al.Department of Hepatic Surgery,Affiliated Provincial Hospital,Anhui Medical University,Hefei 230001,China |
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| Abstract: | Objective To investigate the serum levels of extracellular matrix protein 1（ECM1）,matrix metalloproteinase-9（MMP-9）and vascular endothelial growth factor（VEGF）in patients with HCC.Methods Serum levels of ECM1,MMP-9 and VEGF were detected by enzyme-linked immunosorbent assay in 40 patients with HCC.Results The serum ECM1,MMP-9 and VEGF levels were 150.01±5.85pg/ml,467±30.81μg/l and 751.29±51.08pg/ml;The serum levels of them were significantly associated with tumor capsula,TNM stage,lymph metastasis and Edmondson grade;ECM1 levels was positively correlated with MMP-9 and VEGF levels（r=0.438,P=0.005;r=0.427,P=0.006）.Conclusion ECM1 may stimulate angiogenesis,metastasis and invasion of HCC via interaction with MMP-9 and VEGF. |
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| Keywords: | Hepatoma Extracellular matrix protein 1 Vascular endothelial growth factor Matrix metalloproteinase-9 |
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