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| 唐山地区胃癌患者EB病毒感染与p53基因表达的关系 | |
| 引用本文： | 李淑英,高金兰,夏庆安,周天戟. 唐山地区胃癌患者EB病毒感染与p53基因表达的关系[J]. 肿瘤研究与临床, 2006, 18(2): 100-101 |
| 作者姓名： | 李淑英 高金兰 夏庆安 周天戟 |
| 作者单位： | 1. 063000,河北,唐山,华北煤炭医学院生物系病原生物学科 2. 河北省遵化市水质检验所检验科 3. 唐山市工人医院病理科 |
| 摘 要： | 目的 探讨胃癌患者癌组织中EB病毒感染与p53表达的关系。方法 原位杂交法检测胃癌患者石蜡标本中EB病毒编码的小RNA（EBER1）； 免疫组化法检测EB病毒阳性胃癌及EB病毒阴性胃癌患者标本中抑癌基因p53的表达状况。结果 217例胃癌患者癌组织标本中检测到23例呈EBER1阳性； EB病毒阳性胃癌中P53蛋白表达的平均面积、平均吸光度、积分吸光度值均显著高于EB病毒阴性胃癌（P＜0.05）。结论 EB病毒感染与癌组织中抑癌基因p53的异常表达密切相关。 |
| 关 键 词： | 胃癌 EB病毒感染 p53基因表达 |
| 文章编号： | 1006-9801（2006）02-0100-02 |
| 收稿时间： | 2004-12-07 |
| 修稿时间： | 2005-08-25 |
The influence of EBV infection on p53 expression in gastric carcinoma patients from Tangshan area |
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| LI Shu-ying,GAO Jin-lan,XIA Qing-an,ZHOU Tian-ji. The influence of EBV infection on p53 expression in gastric carcinoma patients from Tangshan area[J]. Cancer Research and Clinic, 2006, 18(2): 100-101 | |
| Authors: | LI Shu-ying GAO Jin-lan XIA Qing-an ZHOU Tian-ji |
| Affiliation: | Department of Biology, North China Coal Medical College, Tangshan 063000, China |
| Abstract: | Objective To investigate the influence of EBV infection on the expression of tumor suppressor gene p53. Methods EBER1 in 217 cases of gastric carcinoma were detected with in situ hybridization. Then, EBV positive and negative cases were selected for analysis of the expression of p53 by immunohistochemistry. Results In 217 cases of gastric carcinoma, there were 23 cases with EBER1 positive. The average area (AA), mean absorbency and integral absorbency of p53 expression were higher in EBV positive gastric carcinoma than those in EBV negative. Conclusions EBV infection of gastric carcinoma is closely related to the expression of p53 in this study. |
| Keywords: | EBV infection p53 expression Gastric carcinoma |
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