| 千金子甲醇提取物抗肿瘤作用的实验研究 |
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| 引用本文： | 黄晓桃,黄光英,薛存宽,孔彩霞,何学斌.千金子甲醇提取物抗肿瘤作用的实验研究[J].肿瘤防治研究,2004,31(9):556-558. |
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| 作者姓名： | 黄晓桃 黄光英 薛存宽 孔彩霞 何学斌 |
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| 作者单位： | 1. 430030,武汉,华中科技大学同济医学院附属同济医院中西医结合研究所
2. 华中科技大学同济医学院附属梨园医院老年医学研究所 |
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| 摘 要： | 目的 观察千金子甲醇提取物体内、外抗肿瘤活性及其量效关系。方法 体外药效试验用MTT法 ,体内用小鼠移植性肿瘤 ,观察千金子甲醇提取物的抑瘤活性。结果 千金子甲醇提取物体外对人宫颈癌细胞 (Hela)、人红白血病细胞 (K562 )、人单核细胞性白血病细胞 (U93 7)、人急性淋巴细胞性白血病细胞 (HL60 )和人肝癌细胞 (HepG2 )的IC50 值分别为 15 .5 μg/ml、13.1μg/ml、10 .5 μg/ml、17.5 μg/ml、2 9 .6 μg/ml;体内对小鼠移植性肿瘤细胞株也显示出较显著抑制作用。 结论 千金子甲醇提取物体外对Hela、K562 、U93 7、HL60 、HepG2 有明显的细胞毒活性 ,体内对小鼠肉瘤 180 (S180 )和艾氏腹水癌 (EAC)也显示出较好的抑制作用
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| 关 键 词： | 千金子甲醇提取物 MTT法 人癌细胞株 肉瘤180 艾氏腹水癌 抗肿瘤 |
| 文章编号： | 1000-8578(2004)09-0556-03 |
| 收稿时间： | 2003-6-9 |
| 修稿时间： | 2003-8-14 |
Experimental Study on the Anti-tumor Effect of Methanolic Extractive from Euphorbia Lathyris L.in Vitro and in Vivo |
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| HUANG Xiao-tao,HUANG Guang-ying,XUE Cun-kuan,KONG Cai-xia,HE Xue-bin.Experimental Study on the Anti-tumor Effect of Methanolic Extractive from Euphorbia Lathyris L.in Vitro and in Vivo[J].Cancer Research on Prevention and Treatment,2004,31(9):556-558. |
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| Authors: | HUANG Xiao-tao HUANG Guang-ying XUE Cun-kuan KONG Cai-xia HE Xue-bin |
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| Institution: | 1.Institute of Integrated Traditional Chinese &; Western Medicine; Tongji Medical college; Huazhong University of Science and Technology; Wuhan 430030; China; 2. Geriatric Institute; Liyuan Hospital; Tongji Medical College; Huazhong University of Science and Technology; |
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| Abstract: | Objective To study the antitumor activity of methanolic extractive from Euphorbia Lathyris L. both in vitro and in vivo, and further evaluate its does-effect relationship.Methods In vitro and in vivo study on the pharmacological activity of methanolic extractive from Euphorbia Lathyris L. were performed by using MTT assay and mice transplant tumor model respectively. Results IC (50) numerical value of Hela cells、K (562) cells、U (937) cells、HL (60) cells and HepG 2 cells were (15.5)μg/m... |
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| Keywords: | Methanolic extractive from Euphorbia lathyris L MTT method Tumor cells S (180) EAC Anti-tumor action |
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