Allelic frequencies of twelve dinucleotide repeat marker loci on chromosome 13 in the normal Japanese population |
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| Authors: | Yuka Yamane Yusuke Nakamura Minoru Isomura |
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| Affiliation: | (1) Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, 108 Tokyo, Japan;(2) Department of Human Genome Analysis, The Cancer Chemotherapy Center, Foundation for Cancer Research, 1-37-1 Kami-ikebukuro, Toshima-ku, 170 Tokyo, Japan |
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| Abstract: | Summary To establish a genotypic database for dinucleotide repeat marker loci in the Japanese population, we determined allelic frequencies of 12 such markers on chromosome 13 and compared them with data from Caucasians in the GDB archive. The average heterozygosity (79%) for the 12 loci was the same for the two populations. However, allelic distributions at two of the marker loci were quite different. These data will be useful for disease studies in the Japanese population that involve linkage or sibship-pair analyses, or association studies. |
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| Keywords: | microsatellite marker allelic distribution linkage analysis |
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