磁共振成像脑微出血与抗栓治疗脑出血相关

目的 观察脑微出血是否与抗栓治疗颅内出血(ICH)相关。方法 选择本院从2005年6月至2010年6月共43例抗栓治疗的脑出血患者，选择同期年龄、性别、高血压史相匹配的非抗栓治疗的脑出血患者及无脑出血史的抗栓药物使用患者作对照。结果 抗栓治疗脑出血组较无脑出血史的抗栓药物组更易发生脑微出血31/43(72.1％)与12/57(21.1％)，x2=6.731，P=0.011]，抗栓治疗脑出血组较非抗栓治疗脑出血组更易发生脑微出血31/43 (72.1％)与17/48 (35.4％)，x2 =4.971，P=0.030]。脑叶微出血在抗栓治疗脑出血组为27/43(62.8％)，而在非抗栓治疗脑出血组为19/48 (39.6％)，两组比较差异有统计学意义(x2=4.019，P=0.042)。脑微出血数目是抗栓治疗脑出血的危险因素（OR=1.38，95％CI 1.07～1.71，t=0.806，P=0.021）。结论 脑微出血与抗栓治疗脑出血相关。

Cerebralmicrobleeds on magnetic resonance imaging associated with antiplatelet-related intracranial hemorrhage

Objective To investigate whether brain microbleeds is associated with antiplatelet-related intracranial hemorrhage (ICH). Methods Forty-three patients with antiplatelet-related ICH treated in our hospital from Jun 2005 to Jun 2010 were investigated in this study. Age, sex and hypertension matched controls with non-antiplatelet-related ICH; and without history of ICH on antiplatelet therapy were selected. Results Microbleeds was more frequent in antiplatelet users with ICH than in matched antiplatelet users without ICH(31/43(72. 1％ ) vs 12/57(21.1％ ), x2 =6. 731, P =0. 011 ) and was more frequent in IHC patients with antiplatelet treatment than those with non-antiplatelet treatment (31/43 (72. 1％ ) vs 17/48 (35.4％), P =0. 030). The frequency of lobar microbleeds(27/43, 62. 8％ ) was significant high in antiplatelet-related ICH than that in non antiplatelet-related ICH (19/48, 39. 6％, x2 =4. 019, P =0. 042). The number of microbleeds was associated with the risk of antiplate-related ICH ( OR =1.38 per additional microbleed, 95％ CI 1.07-1.71, t =0. 806, P =0. 021 ). Conclusion Brain microbleeds are associated with antiplatelet-related ICH.