| 白血病K562/A02细胞Mdr1基因的表达及解毒化淤药干预作用研究 |
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| 引用本文： | 李玉莹,马武开,严鲁萍,姚宇红,黄礼明,姚血明.白血病K562/A02细胞Mdr1基因的表达及解毒化淤药干预作用研究[J].时珍国医国药,2011(6). |
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| 作者姓名： | 李玉莹 马武开 严鲁萍 姚宇红 黄礼明 姚血明 |
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| 作者单位： | 贵阳中医学院第二附属医院; |
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| 基金项目： | 国家自然科学基金(No.30860353); 贵州省高层次人才科研特助项目 |
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| 摘 要： | 目的探讨解毒化淤药含药血清对白血病K562/A02细胞Mdr1耐药基因表达的影响。方法应用半定量逆转录聚合酶链反应(RT-PCR)法检测解毒化淤药含药血清处理后K562/A02细胞Mdr1基因的表达,并与干扰素作对照。结果解毒化淤药含药血清能够降低K562/A02细胞Mdr1基因的表达。结论解毒化淤药含药血清通过降低K562/A02细胞Mdr1耐药基因的表达,逆转白血病细胞耐药。
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| 关 键 词： | 白血病 多药耐药 K562/A02细胞 Mdr1 解毒化淤药 |
Expression of Multidrug Resistance Gene1(Mdr1)of Leukemia k562/A02 Cell and the Intervention of Jieduhuayu Chinese Herbal Serum |
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| LI Yu-ying,MA Wu-kai,YAN Lu-ping,YAO Yu-hong,HANG Li-ming,YAO Xue-ming.Expression of Multidrug Resistance Gene1(Mdr1)of Leukemia k562/A02 Cell and the Intervention of Jieduhuayu Chinese Herbal Serum[J].Lishizhen Medicine and Materia Medica Research,2011(6). |
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| Authors: | LI Yu-ying MA Wu-kai YAN Lu-ping YAO Yu-hong HANG Li-ming YAO Xue-ming |
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| Institution: | LI Yu-ying,MA Wu-kai,YAN Lu-ping,YAO Yu-hong,HANG Li-ming,YAO Xue-ming(The Second Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Guiyang,550003,China) |
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| Abstract: | |
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| Keywords: | Leukemia Multidrug resistance K562/A02 cell Mdr1 Jiedu Huayu Chinese herbal medicine |
| 本文献已被 CNKI 等数据库收录！ |
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