PRKAA2基因单核苷酸多态性与骨科术后深静脉血栓的相关性研究

背景：腺苷酸活化蛋白激酶α2亚基（AMPKα2）被证实参与调控血小板的活化过程,并可能通过调控肌细胞形态与功能影响血栓的发生、发展。目的：探索AMPKα2的编码基因PRKAA2单核苷酸多态性（rs2143749）与骨科术后深静脉血栓（DVT）的相关性。方法：共收集828例骨科手术患者,其中DVT组255例,术后发生DVT;非DVT组573例,术后未发生DVT。分析828例患者rs2143749的基因型和等位基因频率,比较DVT组与非DVT组基因型和等位基因频率的差异。结果：DVT组与非DVT组患者中rs2143749的基因型和等位基因频率无显著性差异（P〉0.05）。结论：PRKAA2单核苷酸多态性（rs2143749）与骨科术后DVT无相关性。

Association of a single nucleotide polymorphism in PRKAA2 with deep vein thrombosis after orthopedic surgery

Background： Adenosine monophosphate（AMP）-activated protein kinase α2 subunit（AMPKα2） encoded by protein kinase,AMP-activated, alpha 2 catalytic subunit（PRKAA2） is involved in the process of platelet activation, and plays an important role in regulating muscle cell function ultimately modulating the thrombogenesis.Objective： To evaluate the association between the PRKAA2 polymorphism（rs2143749） and deep vein thrombosis（DVT）after orthopedic surgery.Methods： A case-control study was performed in 255 DVT subjects（189 females and 66 males） and 573 matched controls without DVT（354 females and 219 males）. Genotypic and allelic frequencies were compared between DVT subjects and control subjects.Results： No significant difference was detected in genotypic or allelic frequencies between DVT subjects and control subjects（all P〉0.05）.Conclusions： PRKAA2 polymorphism（rs2143749） is not a risk factor for deep vein thrombosis after orthopedic surgery in the Chinese Han population.