| 巯嘌呤甲基转移酶检测在炎症性肠病治疗中的作用 |
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| 引用本文： | 董显文,郑青,冉志华. 巯嘌呤甲基转移酶检测在炎症性肠病治疗中的作用[J]. 胃肠病学, 2009, 14(9): 555-557. DOI: 10.3969/j.issn.1008-7125.2009.09.011 |
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| 作者姓名： | 董显文 郑青 冉志华 |
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| 作者单位： | 1. 上海交通大学医学院附属仁济医院消化内科
2. 上海市消化疾病研究所,200001 |
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| 摘 要： | 巯嘌呤甲基转移酶（TPMT）是硫唑嘌呤（AZA）／6-巯基嘌呤（6-MP）代谢的关键酶之一，而AZA／6-MP广泛用于难治性炎症性肠病（IBD）的治疗。TPMT的活性／基因型与AZA／6-MP的疗效和不良反应相关，进行TPMT活性／基因型检测有可能预测骨髓抑制等不良反应的发生，并能指导个体化治疗。
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| 关 键 词： | 甲基转移酶类 炎性肠疾病 治疗 |
Role of Thiopurine S-Methyltransferase Detection in the Treatment of Inflammatory Bowel Disease |
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| DONG Xianwen,ZHENG Qing,RAN Zhihua. Role of Thiopurine S-Methyltransferase Detection in the Treatment of Inflammatory Bowel Disease[J]. Chinese Journal of Gastroenterology, 2009, 14(9): 555-557. DOI: 10.3969/j.issn.1008-7125.2009.09.011 |
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| Authors: | DONG Xianwen ZHENG Qing RAN Zhihua |
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| Affiliation: | ( Department of Gastroenterology, Renji Hospital, Shanghai JiaotongUniversity School of Medicine Shanghai Institute of Digestive Disease, Shanghai (200001)) |
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| Abstract: | Thiopurine S-methyltransferase （TPMT） is a key enzyme in the metabolism of azathioprine （AZA）/6- mercaptopurine （6-MP）, which are widely used in the treatment of inflammatory bowel disease （IBD）. TPMT activity/ genotype is closely associated with the therapeutic effect and adverse reactions of AZA/6-MP. It is possible to predict the myelosuppression and to direct individualized treatment by detecting TPMT activity/genotype. |
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| Keywords: | Methyltransferases Inflammatory Bowel Diseases Therapy |
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