Expression of steroid receptors in intact rat uterus, mammary gland, and liver treated with selective estrogen receptor modulators and conjugated equine estrogens |
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Authors: | Merih Bayram MD Orhan Bayram MD Ayse Dursun MD Ipek Isik MD Ergin Dilekoz Vet D Secil Ozkan MD |
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Affiliation: | (1) Department of Gynecology and Obstetrics, Kirikkale University Faculty of Medicine, Kirikkale, Turkey;(2) Department of General Surgery Section of Breast and Endocrine Surgery, Turkey;(3) Department of Pathology, Turkey;(4) Department of Pharmacology, Turkey;(5) Department of Public Health, Gazi University Faculty of Medicine, Ankara, Turkey |
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Abstract: | The aim of the present study was to determine the effects of conjugated equine estrogens (CEE) and selective estrogen receptor modulators (SERM) (tamoxifen [TAM] and raloxifene [RAL]) on the expression of steroid receptors—estrogen receptor (ER) and progesterone receptor (PR)—in intact rat uterus, mammary gland, and liver. A total of 24 female rats weighing 250 to 300 g were randomized into 4 groups. Groups 1, 2, 3, and 4 were respectively given conjugated equine estrogen, tamoxifen, raloxifene, and vehicle for a 28-day period. ER and PR expression was detected in tissues of the uterus, mammary gland, and liver. Uterine wet weight and serum estradiol levels were established for all groups. No statistical difference was observed between groups in the ER expression of mammary gland and liver and in the PR expression of uterus, mammary gland, and liver, but differences were noted in serum estradiol levels and uterine ER expression. Serum estradiol levels were lower in the TAM-treated group; differences between the TAM-treated group and the other groups were statistically important (P > .05). Uterine ER expression was greater in the CEE-treated group; differences between the CEE-treated group and theTAM and RAL-treated groups were statistically important (P > .05). CEE or SERM versus vehicle treatment in controls did not seem to result in statistically important differences in ER and PR expression in intact rat uterus, mammary gland, and liver. Only ER expression in the uterus was found to be greater in the CEE-treated group than in SERM-treated groups. |
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Keywords: | conjugated equine estrogens CEE selective estrogen receptor modulators SERM estrogen receptor expression progesterone receptor expression |
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