| NO与PGE1对肺动脉高压犬血流动力学影响的对比研究 |
| |
| 引用本文： | 刘明华 毕敏. NO与PGE1对肺动脉高压犬血流动力学影响的对比研究[J]. 中华麻醉学杂志, 1996, 16(11): 547-550 |
| |
| 作者姓名： | 刘明华 毕敏 |
| |
| 作者单位： | 第三军医大学西南医院ＩＣＵ |
| |
| 摘 要： | 对比研究了吸入ＮＯ与静脉输注ＰＧＥ１治疗肺微血管栓塞肺动脉高压犬的血流动力学效果，结果表明，ＮＯ与ＰＧＥ１均显著降低肺动脉压和肺循环阻力，但ＰＧＥ１显著影响体循环，而ＮＯ组心率、血压和体循环阻力均无明显变化，提示ＮＯ比ＰＧＥ１更具有肺血管扩张选择性，治疗肺动脉高压ＮＯ明显优于ＰＧＥ１。
|
| 关 键 词： | 一氧化氮 前列腺素E_1 肺动脉高压 血流动力学 |
Influenceofnitricoxideinhalationonhemodynamicsinpulmonaryhypertensivedogs:AcomparisonwithprostaglandinE1 |
| |
| LiuMinghua,BiMin.SouthwestHospital,ThirdMilitaryMedicalUniversity,Chongqing. Influenceofnitricoxideinhalationonhemodynamicsinpulmonaryhypertensivedogs:AcomparisonwithprostaglandinE1[J]. Chinese Journal of Anesthesilolgy, 1996, 16(11): 547-550 |
| |
| Authors: | LiuMinghua BiMin.SouthwestHospital ThirdMilitaryMedicalUniversity Chongqing |
| |
| Affiliation: | LiuMinghua,BiMin.SouthwestHospital,ThirdMilitaryMedicalUniversity,Chongqing630038 |
| |
| Abstract: | Toevaluatetheefectsofnitricoxide(NO)onhemodynamicsinpulmonaryhypertensivedogs,eighteenadultmongreldogswithpulmonaryhypertensioninducedbymicroemboli,wererandomlydividedintothreegroups,eachreceivedintravenousnormalsaline,prostaglandinE1(PGE1)orinhaledNOfortwohours.Alhemodynamicparameterswerestableinthecontrolgroup;Thereweresignificantdecreaseinmeanpulmonaryarterypressure(MPAP)andpulmonaryvascularresistanceindex(PVRI)whileheartrate(HR),meansystemicarterypressure(MSAP),systemicvascularresistanceindex(SVRI)toNo,andcardiacindex(CI)remainedstableininhaledNOgroup;PGE1hadsimilarefectonMPAPandPVRI,buthadasingnificantinfluenceonsystemiccirculation.Theresultssuggestthatin-halingNOhasseletivevasculardilatationeffectonpulmonarycirculationandissuperiortoPGE1inthetreatmentofpulmonaryhypertension. |
| |
| Keywords: | NitricoxideProstaglandinE1PulmonaryhypertensionHemodynamics |
| 本文献已被 CNKI 维普 等数据库收录！ |
