铅对生长发育期小鼠学习记忆行为及脑内NO含量的影响

目的　探讨长期低铅染毒对生长发育期小鼠学习记忆行为影响的机制。方法　采用开场试验、T型水迷宫等行为观察和生化检测相结合的方法 ,观察长期低铅染毒对生长期小鼠学习记忆及脑内NO、SOD活性及MDA含量的变化。结果　与对照组相比 :(1) 0 .0 75 %醋酸铅染毒组小鼠学习能力呈明显损伤 (P <0 .0 1) ;(2 ) 0 .0 75 %醋酸铅染毒组小鼠脑内NO含量、SOD活性明显下降 (P <0 .0 1) ,而MDA含量明显升高 (P <0 .0 1)。结论　长期低铅染毒对生长发育期小鼠学习能力有显著损伤 ,这种损伤可能与脑内NO含量、SOD活性下降、MDA含量升高有一定的相关性。

The influence of lead on learning memory behaviors of growing mice and the contents of in the brain

Objective To study the mechanism of lead exposure on the capability of learning memory behavior in growing mice . Method The experimental mice were divided into four groups, which were intoxicated with oral exposure to lead acetate (0.025%,0.05%,0.075% group) and distilled water (control group)for 8 weeks, respectively. The changes of learning and memory were observed in open field ,T water-maze test. The contents of NO,MDA and activity of SOD in mice's brain were investigated by biochemical measurement. Results Compared with control (1) the learning ability decreased in 0.075% group mice ( P <0.01);(2)the content of NO and activity of SOD in mice's brain was lower in 0.075% group ( P <0.01), but MDA was higher( P < 0.01 ). Conclusion Low lead exposure could significantly damage the capacity of learning and this damages may be related with the contents of NO, MDA and activity of SOD in mice's brain.