2型糖尿病患者血管性假血友病因子与糖尿病肾病关系的研究

目的 探讨糖尿病肾病不同时期血清血管性假血友病因子(vWF)浓度的变化及意义。方法 正常对照组50例和2型糖尿病组150例纳入本研究，根据尿白蛋白排泄率(UAER)将糖尿病患者分为正常蛋白尿组(56例)、微量白蛋白尿组(49例)和临床蛋白尿组(45例)。采用ELISA法检测血清vWF浓度。结果 2型糖尿病患者血清vWF浓度较对照组明显升高；血清vWF浓度随UAER的增加而增加；多元逐步回归分析表明vWF与UAER、血肌酐(Cr)及病程呈正相关。结论 2型糖尿病患者血清vWF升高，而且vWF升高的强度与糖尿病肾病的程度存在一致性。

Relationship between Serum Von Willebrand Factor and Diabetic Nephropathy in Type 2 Diabetic Patients

Objective To investigate the change of serum von willebrand factor(vWF)level in the different stages of diabetic nephropathy and its significance. Methods 50 healthy subjects and 150 patients with type 2 diabetes mellitus were enrolled in this study. Diabetic patients were further divided into three subgroups according to their urinary albumin excretion rate(UAER): 56 patients with normal UAER,49 patients with microalbuminuria and 45 patients with clinical proteinuria. Serum vWF concentration was measured with emzyme linked immunosorbent assay (ELISA) method. Results vWF concentration was significantly higher in patients with type 2 diabetes mellitus than that in normal controls. Serum vWF concentration increased with the elevation of UAER. Serum vWF level was positively related with UAER, blood creatine and course of disease independently. Conclusion Serum vWF concentration increased in the patients with type 2 diabetes mellitus and the increased extent of vWF was consistent with the severe degree of diabetic nephropathy.