| 盐酸伊伐布雷定对单硝酸异山梨酯在比格犬体内的药动学影响 |
| |
| 引用本文： | 商庆节.盐酸伊伐布雷定对单硝酸异山梨酯在比格犬体内的药动学影响[J].现代药物与临床,2015,38(1):53-55. |
| |
| 作者姓名： | 商庆节 |
| |
| 作者单位： | 鲁南制药集团股份有限公司, 山东 临沂 273400 |
| |
| 摘 要： | 目的 研究盐酸伊伐布雷定对单硝酸异山梨酯在比格犬体内的药动学影响.方法 采用HPLC法测定单硝酸异山梨酯单独给药或联合盐酸伊伐布雷定给药后不同时间比格犬体内的血药浓度,采用非房室模型计算单硝酸异山梨酯药动学参数.结果 单硝酸异山梨酯单独给药及与盐酸伊伐布雷定联合使用后,在比格犬体内单硝酸异山梨酯的主要药动学参数差异无统计学意义(P<0.05).单硝酸异山梨酯联合盐酸伊伐布雷定给药相对单硝酸异山梨酯单独给药的生物利用度为100%.结论 盐酸伊伐布雷定与单硝酸异山梨酯联合用药后对单硝酸异山梨酯在比格犬体内的药动学过程无影响.
|
| 关 键 词： | 盐酸伊伐布雷定 单硝酸异山梨酯 比格犬 药动学 |
| 收稿时间： | 2014/10/20 0:00:00 |
Effect of Ivabradine on isosorbide-5-mononitrate pharmacokinetics in Beagle's dogs |
| |
| SHANG Qing-jie.Effect of Ivabradine on isosorbide-5-mononitrate pharmacokinetics in Beagle's dogs[J].Drugs & Clinic,2015,38(1):53-55. |
| |
| Authors: | SHANG Qing-jie |
| |
| Institution: | Lunan Pharmaceutical Group Corporation, Linyi 273400, China |
| |
| Abstract: | Objective To study the effect of Ivabradine on isosorbide-5-mononitrate (5-ISMN) pharmacokinetics in Beagle's dogs. Methods The plasma concentration of 5-ISMN was determined by HPLC after taking single or combined Ivabradine administration in Beagle's dogs. The pharmacokinetics parameters of 5-ISMN were calculated using the non-compartmental analysis. Results Non-statistically significant differences have been observed for the main pharmacokinetic parameters of 5-ISMN when administered alone or with Ivabradine (P < 0.05). Compared with single drug administration, the relative bioavailability of 5-ISMN administered with Ivabradine was 100%. Conclusion There is no effect of 5-ISMN combined with Ivabradine on pharmacokinetics of 5-ISMN in Beagle's dogs. |
| |
| Keywords: | Ivabradine isosorbide-5-mononitrate Beagle's dogs pharmacokinetics |
|
| 点击此处可从《现代药物与临床》浏览原始摘要信息 |
| 点击此处可从《现代药物与临床》下载免费的PDF全文 |
