老年高血压患者踝肱指数与尾加压素Ⅱ相关性研究

目的：研究老年高血压患者踝肱指数与尾加压素Ⅱ（UⅡ）的相关性，进一步探讨UII与动脉粥样硬化的关系。方法：采用放免法测定130例老年高血压患者及72例健康老年人血浆UⅡ浓度，并分别测量踝肱指数（anklebrachialindex，ABI），再根据ABI严重程度将高血压患者分为ABIO、ABI1、ABI2三组。结合UⅡ水平、踝肱指数对各组进行比较分析。结果：与健康组比较，高血压患者踝肱指数明显降低，而血浆UⅡ水平明显升高（P〈0．01）；高血压患者血浆UⅡ水平与ABI呈明显负相关，高血压三组UⅡ水平组间比较差异有统计学意义（P〈0．05）。结论：老年高血压患者的踝肱指数与血浆uⅡ水平呈负相关，提示UⅡ浓度与动脉粥样硬化密切相关。

The Relationship of Ankle-brachial Index and Urotensin II in Elderly Patients with Hypertension

Objective： To study the relationship of ankle-brachial index and urotensin Ⅱ （ UⅡ ）in elderly patients with hypertension, to explore the relationship of UⅡ and atherosclerosis. Method： To enroll 130 eases of elderly patients with hypertension and 72 healthy elderly, the plasma UⅡ concentration and the ankle-brachial index （ ankle brachial index, ABI ） was measured by radioimmunoassay in all cases.According to the severity of the ABI, the hypertensive patients were divided into ABI0/ABI1/ABI2 three groups. At last, a comprehensive analysis of UⅡ level, ankle- brachial index, in each group was deployed.Result： Compared with the healthy individuals, the ankle-brachial index in hypertensive patients was significantly reduced, in contrast the plasma UⅡ levels were significantly increased （P〈0.01） .The plasma UⅡ level was negatively related to the ABI in hypertensive patients.The difference of UⅡ level in three hypertensive groups was statistically significant （ P〈0.05 ） .Conclusion： ABI in elderly hypertensive patients is negatively related with the plasma U ff level and the concentration of UⅡ is closely related to the Atherosclerosis.