吡罗昔康新制剂微乳的药效学研究

目的：制备吡罗昔康微乳新剂型，对其抗炎、镇痛作用进行初步药效学研究，观察连续用药对皮肤组织形态学的改变，并与凝胶制剂进行比较。方法：采用油相Lauroglycol FCC，表面活性剂Labrasol、Cremophor EL，助表面活性剂TranscutolP、吡罗昔康及水制备吡罗昔康微乳，1％的双氯芬酸钠凝胶剂作为阳性对照药，采用二甲苯诱导小鼠耳廓肿胀，卡拉胶诱发大鼠足跖肿胀，痛阈提高率和醋酸致小鼠扭体实验，对吡罗昔康微乳的抗炎镇痛作用进行初步探讨并与市售的吡罗昔康凝胶进行比较。结果：吡罗昔康微乳具有抗炎镇痛作用，中、低剂量的吡罗昔康微乳与阳性对照组比较均显示相近或更强的抗炎镇痛作用，与吡罗昔康凝胶组比较，作用强、时间长、效果平稳，且对皮肤无刺激性。结论：吡罗昔康新制剂微乳安全，抗炎镇痛作用明显，有望成为吡罗昔康的新型制剂。

Study the Anti-inflammatory and Analgesic Effects of Piroxicam Microemulsions on Mice

Objective： To prepare piroxicam miroemulsion and study its anti-inflammatory and analgesic effects, observe the continuous medication on skin morphology, and compare with piroxiam gel. Method： The microemulsion was prepared with the system contained of Lauroglycol FCC as oil phase, Labrasol and Cremophor EL as surfactants, Transcutol P as consurfactants, piroxicam, water 1% dichlofenac sodium gel was used as positive control, xylene and carrageenan were used to induce ear edema in mice and pedal swelling in rats respectively in order to study anti-inflammatory effect of Piroxiam microemulsion. The hot-plate test and writhing test was adopted to study the analgesic effect, then compared with Piroxiam gel. Result： Middle dose and high dose Piroxiam miroemulsion was equal or superior to positive control in anti-inflammatory and analgesic effect. Compared with piroxiam gel, it had longer action time and more stable effects. In addition, there was no irritation to the skin. Conclusion： Piroxiam miroemulsion has significant antiinflammatory and analgesic effects, it is expected to become a new formulation.