| Smad蛋白研究进展 |
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| 引用本文： | 庞莉,王晶,蒋延文.Smad蛋白研究进展[J].现代保健,2013(12):155-159. |
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| 作者姓名： | 庞莉 王晶 蒋延文 |
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| 作者单位： | [1]解放军总医院呼吸内科博士研究生,北京100853 [2]首都医科大学附属北京世纪坛医院,北京100853 |
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| 摘 要： | Smad蛋白家族是转化生长因子β（TGFβs）超家族重要的细胞因子，共同担负着调节细胞生长、分化、凋亡等过程，主要由8种不同的蛋白构成整个Smad家族，通过可逆磷酸化对多种信号传导通路的功能起着荚键的调节作用，分别行使兴奋和抑制等不同作用。本文对Smad蛋白调节作用机制进行综述。
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| 关 键 词： | Smad蛋白 TGFβs 磷酸化 |
The Research Progress of Smad Proteins |
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| Authors: | PANG Li WANG Jing JIANG Yan-wen |
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| Institution: | (Medical Innovation of China) |
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| Abstract: | The Smad family of proteins is importan! mediators of the transforming growth factor-beta （ TGFβs ） family of cytokines jointlycharges with the regulation of cell growth, differentiation, and apoptosis process. It is mainly constituted by eight different proteins and plays a key role in regulating the function of a variety of signal transduction pathways through reversible phosphorylation, exercising excitatory and inhibilory effects. Thisreview discusses Smad protein regulating mechanism. |
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| Keywords: | Smad proteins TGFβ s Phosphorylation |
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