地佐辛超前镇痛对腹腔镜手术患者术中应激反应的影响

目的：观察地佐辛切皮前给药对腹腔镜胆囊切除手术患者术中应激反应的影响。方法：选择40例全麻下行腹腔镜胆囊切除手术患者，ASA分级Ⅰ～Ⅱ级，随机分为两组，Ⅰ组采用异丙酚、瑞芬太尼静脉复合全麻，Ⅱ组在异丙酚、瑞芬太尼静脉复合全麻的基础上，于术前10min静注地佐辛0．1mg／kg。观察两组患者术中血流动力学变化及拔管时间；测定人室后、插管后1min、切皮后10rain和拔管后5min血糖和皮质醇的变化。结果：Ⅱ组术中MAP、HR均比Ⅰ组降低（P〈0．05），Ⅰ组术中皮质醇测定高于Ⅱ组（P〈0．05）。术后Ⅰ组血糖高于Ⅱ组（P〈0．01）。结论：地佐辛超前镇痛可减轻患者术中应激反应。

The Effect of Dezocine Preemptive Analgesia to Stress Response during Operation for Laparoscopic Cholecystectomy Patients

Objective： To observe the effect of dezocine to stress response during operation for laparoscopic cholecystectomy patients. Method： To select 40 laparoscopic cholecystectomy patients, ASA classification I - II, who were randomly divided into 2 groups, I group with propofol and remifentanil vein complex anesthesia, II group on the basis of I group, patients were injected dezocine 0.1 mg/kg after operation 10 min. To observe the two groups＇ haemodynamic changes and extubation time during operation, and measure changes of the plasma Cor and plasma glucose after patients entering operation room, intubation, cutting the skin 10 minutes and extubation. Result： The MAP, HR during operation of II groups was lower than that of I group （ P〈0.05 ）, cortisol measurement during operation of I group was higher than that of II group （ P〈0.05 ） . Blood sugar of I group after operation was higher than that of II group （ P〈0.01） . Conclusion： Dezocine preemptive analgesia can reduce stress response during operation.