| 荜茇挥发油清除自由基作用及其与分子结构的关系 |
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| 引用本文： | 李熙灿,赵小军,谢学明,钟远声,黄春花,陈东风.荜茇挥发油清除自由基作用及其与分子结构的关系[J].中药新药与临床药理,2006,17(3):218-221. |
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| 作者姓名： | 李熙灿 赵小军 谢学明 钟远声 黄春花 陈东风 |
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| 作者单位： | 广州中医药大学基础医学院,广州,510405 |
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| 基金项目： | 国家自然科学基金项目(30271377,30371837,30472272)，广东省自然科学基金项目(31483) |
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| 摘 要： | 目的观察海南产荜茇挥发油清除自由基活性,探讨其与分子结构的关系。方法DPPH法检测清除自由基活性;GC-MS法分析其化学成分,并用谱库检索确定各化合物结构。结果①荜茇挥发油具有清除DPPH自由基的能力,且浓度越高,活性越强;②海南产荜茇挥发油含41个化合物,碳碳双键C=C的相对含量占绝对优势。结论碳碳双键C=C可能为荜茇挥发油清除自由基活性的必需官能团。
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| 关 键 词： | 荜茇 挥发油 1 1-二苯基-2-苦基肼基自由基 官能团 GC-MS |
| 文章编号： | 1003-9783（2006）03-0218-04 |
| 收稿时间： | 2006-01-12 |
| 修稿时间： | 2006年1月12日 |
Free Radical Scavenging Action of Volatile Oil from Piper longum L. and Its Relationship with Molecular Structure |
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| LI Xican,ZHAO Xiaojun,XIE Xueming,ZHONG Yuansheng,HUANG Chunhua,CHEN Dongfeng.Free Radical Scavenging Action of Volatile Oil from Piper longum L. and Its Relationship with Molecular Structure[J].Traditional Chinese Drug Research & Clinical Pharmacology,2006,17(3):218-221. |
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| Authors: | LI Xican ZHAO Xiaojun XIE Xueming ZHONG Yuansheng HUANG Chunhua CHEN Dongfeng |
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| Institution: | 1. College of Chinese Materia Medica, Guangzhou University of TCM, Guangzhou 510405; 2. College of Basic Medicine, Guangzhou University of TCM, Guangzhou 510405 |
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| Abstract: | Objective To observe the free radical scavenging action of volatile oil from Piper longum L.growing in Hainan Province and to explore the relationship of the action with molecular structure.Methods 1,1-Diphenyl-2-picrylhydrazyl radical(DPPH) method was used to determine the scavenging action.The components of volatile oil were analyzed by GC-MS,and their molecular structures were identified by databank.Results(1)The volatile oil from Piper longum L.had scavenging actions on free radicals in a concentration-dependent manner.(2)Forty one compounds were found in volatile oil from Piper longum L.growing in Hainan Province,in which the amount of carbon-carbon double bond(C=C) was in predomination.Conclusion Carbon-carbon double bond(C=C)is the essential functional group for free radical scavenging action of volatile oil from Piper longum L. |
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| Keywords: | Piper longum L Volatile oil DPPH(1 1-Diphenyl-2-picrylhydrazyl) Functional group GC-MS |
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