Cost-effectiveness of second-line treatment with irinotecan or infusional 5-fluorouracil in metastatic colorectal cancer |
| |
Authors: | C. Levy-Piedbois I. Durand-Zaleski H. Juhel C. Schmitt A. Bellanger P. Piedbois |
| |
Affiliation: | (1) Department of Public Health and Informatics, Institut Gustave Roussy, Villejuif, France;(2) Department of Public health, Hôpital Henri Mondor, AP-HP, Paris, France;(3) Pharmacy, Hôpital Pitiè-Salpétrière, AP-HP, Paris, France;(4) ARCOS, Issy-les-Moulineaux, France;(5) Department of Oncology, Hôpital Henri Mondor, AP-HP, Paris, France |
| |
Abstract: | Background:It has been shown that irinotecan is superior toinfusional 5-fluorouracil (5-FU) in patients with advanced colorectal cancerafter 5-FU failure. In a recent trial, median survival was 10.8 months forpatients treated with irinotecan, compared to 8.5 months in patients receivinginfusional 5-FU. Considering the statistically significant but clinicallyrelatively small advantage of irinotecan over 5-FU, cost effectiveness shouldalso be part of treatment decision.Purpose:To relate the costs of each management approach tooverall survival in patients with metastatic colorectal cancer.Patients and methods:The healthcare costs and medical benefits(treatment-added survival) of second-line chemotherapy in patients (infusional5-FU: 129, irinotecan: 127) were compared. Data on overall survival were drawnfrom a multicenter randomised trial that compared infusional 5-FU (continuousinfusion, AIO, or LV5-FU2 regimens) to irinotecan alone. Costs were derivedfrom the accounting system in two university hospitals in Paris, France.Results:The range in total healthcare costs was 14,135 to 12,192US$ patient between management approaches, with irinotecan chemotherapycosting most and 5-FU-continuous infusion least. If survival was included asa treatment benefit, the cost-effectiveness ratio of irinotecan over 5-FUranged from 9,344 to 10,137 US$ per year of added survival.Conclusions:The least expensive management for metastaticcolorectal was 5-FU infusion but the additional cost of irinotecan wasbalanced by the added months of survival, with a cost-effectiveness ratioclose to that of other cancer treatments. |
| |
Keywords: | 5-fluorouracil chemotherapy colorectal cancer cost/effectiveness analysis irinotecan |
本文献已被 Oxford SpringerLink 等数据库收录! |
|