成人散发性病毒性胃肠炎的病原学分析

目的了解北京地区成人散发性病毒性胃肠炎中诺如病毒、轮状病毒及肠道腺病毒感染情况和流行病学特点,为临床防治提供理论依据。方法收集北京大学人民医院2005年至2006年成人肠道门诊散发非霍乱水样便腹泻患者粪便标本312份,用聚丙烯酰胺凝胶电泳（PAGE）进行轮状病毒核酸的检测;分别用德国R—Biopharm公司的酶免疫试剂盒进行诺如病毒和肠道腺病毒抗原的检测。结果312份粪便标本中,轮状病毒核酸检测全部阴性;125份粪便标本中诺如病毒阳性22份,阳性检出率17．6％（22／125）,其中10月份检出率最高,为32．4％（11／34）;92份粪便标本中肠道腺病毒阳性3例,检出率3．3％（3／92）,其中1例诺如病毒和腺病毒混合感染。结论北京地区成人散发性病毒性胃肠炎病原以诺如病毒多见,秋季多发;轮状病毒感染率可能很低。

Etiological study on sporadic viral gastroenteritis among adult in Beijing

OBJECTIVE: To understand the infection and epidemiology of norovirus and rotavirus and enteral adenovirus among adult with sporadic viral gastroenteritis in Beijing and provide theoretical basis for clinical prevention and control. METHODS: Stool specimens were collected from all 312 sporadic outpatient among adult with non-cholera watery diarrhea in Infectious Disease Department of Peking University People's Hospital 2005-2006. PAGE were used for detection of rotavirus RNA in stool specimens; R-Biopharm RIDASCREEN norovirus and RIDASCREEN adenovirus were used for detection of norovirus and adenovirus. RESULTS: Rotavirus RNA was not present in all 312 stool specimens; Norovirus was present in 17.6% (22/125) and in 32.4% (11/34) in October; Adenovirus was present in 3.3% (3/92); Mixed infections of norovirus and adenovirus was present in 1 stool specimen. CONCLUSIONS: Norovirus is more common etiologic agents of sporadic acute viral gastroenteritis among adult in Beijing, The infection peak of norovirus is in autumn. Maybe the infection of rotavirus is few.